Hsu, Peng ChiehPeng ChiehHsuCheng, Po WenPo WenChengYI-HO YOUNG2023-02-162023-02-162015-10-1509574271https://scholars.lib.ntu.edu.tw/handle/123456789/628203OBJECTIVE: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular-evoked myogenic potential (oVEMP), cervical VEMP (cVEMP) and caloric tests to assess inner ear function in patients with long term exposure to organic solvents. METHODS: Eighteen patients exposed to organic solvents and another 18 non-exposed controls from the same environment were enrolled in this study. Each subject underwent an inner ear test battery. RESULTS: The percentages of abnormalities identified by the oVEMP test, cVEMP test, audiometry and caloric test for the exposed group were 85%, 54%, 50% and 33%, respectively, which showed significant differences when compared with the respective 8%, 8%, 6% and 0 for the non-exposed group. Additionally, a significantly declining trend of inner ear deficits from the utricle to the saccule, cochlea, and semicircular canals was noted in the exposed group, but not in the non-exposed group. CONCLUSION: Ototoxicity was identified in those exposed to organic solvents, with the sequence of abnormal inner ear function from the utricle to the saccule, cochlea, and semicircular canals.enCervical vestibular-evoked myogenic potential | Neurotoxicity | Ocular vestibular-evoked myogenic potential | Organic solvent | Ototoxicity | Toluene | Vestibulo-ocular reflexjournal article10.3233/VES-150559267561332-s2.0-84954142218WOS:000365634400008https://api.elsevier.com/content/abstract/scopus_id/84954142218