Siao, Shu-FenShu-FenSiaoTYNG-GUEY WANGSHIH-CHI KUWei, Yu-ChungYu-ChungWeiCHERYL CHIA-HUI CHEN2024-11-082024-11-082024-09-11https://pubmed.ncbi.nlm.nih.gov/39258981/https://scholars.lib.ntu.edu.tw/handle/123456789/722870OBJECTIVES: To investigate the prevalence and association with mortality of inability to perform sit-to-stand independently in critically ill survivors 3 months following medical ICU (MICU) discharge. DESIGN: Prospective cohort study. SETTING: Six MICUs at a tertiary care hospital. PATIENTS: MICU survivors who could sit-to-stand independently before the index hospitalization. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Inability to sit-to-stand (yes/no) was measured at four points following MICU discharge: upon ICU discharge, 1, 2, and 3 months afterward. Mortality was evaluated at 6- and 12-month post-MICU discharge. Among 194 participants, 128 (66%) had inability to sit-to-stand upon MICU discharge. Recovery occurred, with rates decreasing to 50% at 1 month, 38% at 2 months, and 36% at 3 months post-MICU discharge, plateauing at 2 months. Inability to sit-to-stand at 3 months was significantly associated with 21% mortality at 12 months and a 4.2-fold increased risk of mortality (adjusted hazard ratio, 4.2; 95% CI, 1.61-10.99), independent of age, Sequential Organ Failure Assessment score, and ICU-acquired weakness. Notably, improvement in sit-to-stand ability, even from “totally unable” to “able with assistance,” correlates with reduced mortality risk. CONCLUSIONS: Inability to sit-to-stand affects about 36% of MICU survivors even at 3 months post-ICU discharge, highlighting rehabilitation challenges. Revisiting sit-to-stand ability post-ICU discharge is warranted. Additionally, using sit-to-stand as a screening tool for interventions to improve return of its function and mortality is suggested.en[SDGs]SDG3journal article10.1097/CCM.000000000000640439258981