MATAN SHELOMITan T.ZHuang R.Y.-J.2022-12-142022-12-14202100221333https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118699826&doi=10.1007%2fs12041-021-01328-9&partnerID=40&md5=09b37c299d3f7d737e5e52f9c62e8e75https://scholars.lib.ntu.edu.tw/handle/123456789/626060The CP2 transcription factors are highly conserved in metazoans, where they are divided into two groups: grainyhead and late SV40 factor (LSF). We traced their evolutionary history in the Hexapoda using over 500 insect transcriptomes, to test the hypothesis that the evolution of holometaboly involved novel isoforms of these genes. All insects appear to express at least one grainyhead and one LSF-like gene, regardless of life cycle, as in most known metazoa. No major evolutionary events in these gene families occurred during the evolution of insects. © 2021, Indian Academy of Sciences.CP2; grainyhead; insects; late SV40 factor; transcription factor; transcriptome[SDGs]SDG3insect protein; transcription factor; animal; classification; gene; genetics; insect; metamorphosis; molecular evolution; phylogeny; physiology; Animals; Evolution, Molecular; Genes, Insect; Insect Proteins; Insecta; Metamorphosis, Biological; Phylogeny; Transcription Factorsnote10.1007/s12041-021-01328-9347871182-s2.0-85118699826