Li, Y.Y.LiDhawan, U.U.DhawanWang, H.-Y.H.-Y.WangLiu, X.X.LiuKu, H.-H.H.-H.KuTsai, M.-T.M.-T.TsaiYen, H.-W.H.-W.YenChung, R.-J.R.-J.ChungHUNG-WEI YEN2020-05-122020-05-122019https://scholars.lib.ntu.edu.tw/handle/123456789/491414The challenges of nanoparticles, such as size-dependent toxicity, nonbiocompatibility, or inability to undergo functionalization for drug conjugation, limit their biomedical application in more than one domain. Oval-shaped iron@gold core–shell (oFe@Au) magnetic nanoparticles are engineered and their applications in magnetic resonance imaging (MRI), optical coherence tomography (OCT), and controlled drug release, are explored via photo stimulation-generated hyperthermia. The oFe@Au nanoparticles have a size of 42.57 ± 5.99 nm and consist of 10.76 and 89.24 atomic % of Fe and Au, respectively. Upon photo-stimulation for 10 and 15 minutes, the levels of cancer cell death induced by methotrexate-conjugated oFe@Au nanoparticles are sixfold and fourfold higher, respectively, than oFe@Au nanoparticles alone. MRI and OCT confirm the application of these nanoparticles as a contrast agent. Finally, results of in vivo experiments reveal that the temperature is elevated by 13.2 °C, when oFe@Au nanoparticles are irradiated with a 167 mW cm?2 808 nm laser, which results in a significant reduction in tumor volume and scab formation after 7 days, followed by complete disappearance after 14 days. The ability of these nanoparticles to generate heat upon photo-stimulation also opens new doors for studying hyperthermia-mediated controlled drug release for cancer therapy. Applications include biomedical engineering, cancer therapy, and theranostics fields. ? 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheimhyperthermia; nanomedicine; oval-shaped iron@gold core–shell nanoparticles; photo-stimulation; theranostics[SDGs]SDG3Biomedical engineering; Cell death; Chemotherapy; Diseases; Gold nanoparticles; Hyperthermia therapy; Iron; Magnetic resonance imaging; Medical applications; Medical nanotechnology; Nanomagnetics; Nanoparticles; Oncology; Optical tomography; Targeted drug delivery; Biomedical applications; Controlled drug release; Gold cores; hyperthermia; Magnetic nano-particles; Photo stimulations; Size-dependent toxicity; Theranostics; Controlled drug deliveryjournal article10.1002/ppsc.2018004192-s2.0-85065738298https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065738298&doi=10.1002%2fppsc.201800419&partnerID=40&md5=029f71fdc96af19d96a6ec791f040cee