李文宗臺灣大學：流行病學研究所張晉豪Chang, Chin-HaoChin-HaoChang2007-11-272018-06-292007-11-272018-06-292004http://ntur.lib.ntu.edu.tw//handle/246246/56182複雜性遺傳疾病會受基因，基因-環境，以及基因-基因交互作用的影響。以病例對照法估算這些效應，會產生族群分層/融合偏差。採行病例雙親或病例手足研究法，可避免產生偏差。面對晚發性疾病，病例雙親及手足對照的收案會有釵h困難。雖然惟病例法收案容易，可是也有族群分層/融合偏差的問題，而且不能評估基因效應。病例配偶法不僅對照收集較為容易，也可降低基因，基因-環境，以及基因-基因交互作用等估計值的偏差程度。在族群融合比率不高時，幾乎是無偏差。即使在族群融合比率為1時，也與病例對照法的偏差程度相似。因此探討基因定量特徵時，此法應是值得流行病學家採用的方法之一。It is important to characterize the effects of gene, gene-environment, and gene-gene interactions in the study of human complex diseases. The potential bias is raised due to population stratification/admixture in the traditional case-control study. Family-based study, like case-parents and case-siblings study, can circumvent the problem of bias. However, it is difficult to recruit parents or siblings of cases in studies of adult-onset disease. Case-only study can be implemented easily, but it still faces the stratification bias for assessing gene-environment and gene-gene interactions. The novel study, case-spouse study, reduces the bias if the population is stratification or admixture slightly. The estimates have the corresponding coverage probability. It is more convenient to collect the spouse then the parents or siblings of cases. The case-spouse design is an alternative for assessing the genotype relative risks, gene-environment, and gene-gene interaction coefficients.無290105 bytesapplication/pdfen-US流行病學方法學相關研究法基因特徵遺傳流行病學epidemiologic methodsassociation studygenetic epidemiologygene characterization[SDGs]SDG3thesishttp://ntur.lib.ntu.edu.tw/bitstream/246246/56182/1/ntu-93-D88842002-1.pdf