2011-08-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/655137摘要：自1984年7月1日起臺灣施行全民B型肝炎預注射之政策，成功地降低了我國兒童B型肝炎病毒感染率、帶原率以及兒童相關肝病等。性行為是B型肝炎除了母子垂直感染以外另一種重要的傳染途徑，特別是在青少年時期之後。B型肝炎疫苗世代(指的是1986年後新生兒全面接種B型肝炎疫苗的出生世代)已處於青年期（即成年人早期），對於這群幼時曾經打過B型肝炎疫苗卻在青少年或青年期時期檢驗B型肝炎表面抗體消失的人得到B型肝炎病毒感染的機會一直缺乏實證研究提出具體數據佐證是否需要B型肝炎疫苗再接種的建議。因此本研究之目的希望透過北部某大學新生健檢與碩士班健檢資料，加上B型肝炎病毒血清學檢驗資料，建立連續三年B型肝炎疫苗世代B型肝炎感染血清流行病學資料與資料連鎖方式串聯分析，透過連結疾病管制局出生新生兒與學齡前兒童之B型肝炎疫苗預防接種資料庫、孕產婦資料檔、全國癌症發生檔及全國死亡檔，藉以分析了解B型肝炎疫苗世代年輕族群及部分再接種B型肝炎疫苗後B型肝炎感染血清流行病學資料；B型肝炎疫苗世代母親B型肝炎病毒感染相關疾病以及長期健康影響之流行病學。本研究可提供政府青少年及成人早期B型肝炎疫苗再預防接種政策之參考。<br> Abstract: Taiwan has launched a successful nationwide neonatal hepatitis B immunization since July 1, 1984. It successfully decreased the incidence of hepatitis B virus infection, the hepatitis B carrier rate as well as liver diseases among children and adolescents.The sexual transmission route is another important way of hepatitis B infection aside from the mother and child vertical infection, especially for youth and adults.Hepatitis B vaccination cohort refers to those who were born after 1986 and received hepatitis B vaccine immunization during newborn period. They are gradually entering into young adults and adolescent age. Among them, there is no empirical evidence to show the actual infection rate and to help implement hepatitis B vaccine booster policy for those who had three seronegative viral markers of hepatitis B. Therefore, the study design is to collect three consecutive years graduate school students school entry health examination data and undergo three hepatitis B viral markers checkup and blood types. The data linkage includes their health checkup data in the freshmen period, Taiwan CDC databank for neonatal hepatitis B immunization records, pregnancy and birth record registry, Taiwan cancer registry and Taiwan death record registry. This study is aimed to delineate the hepatitis B seroepidemiology among young adults with or without neonatal hepatitis B immunization, among young adults with hepatitis B booster in the university period, among the mothers of hepatitis B vaccination cohort. The results of this study will provide important information to help government implement hepatitis B vaccine booster policy in the adolescents and young adults.青年B型肝炎疫苗血清流行病學young adulthepatitis B virusvaccineseroepidemiology