TSENG-CHENG CHENPEI-JEN LOUJENG-YUH KOTSUNG-LIN YANGLo W.-CHu Y.-LCHENG-PING WANG2020-10-272020-10-2720111068-9265https://www.scopus.com/inward/record.uri?eid=2-s2.0-79951552588&doi=10.1245%2fs10434-010-1294-7&partnerID=40&md5=1912aa3aeeefafb976b5d1832af451afhttps://scholars.lib.ntu.edu.tw/handle/123456789/518269Background: The impact of submandibular gland (SMG) preservation during neck dissection on the survival of patients with early-stage oral squamous-cell carcinoma (OSCC) remains undocumented. Methods: The medical records of all patients with early-stage OSCC (stage I and II) who underwent wide excision of the primary tumor and simultaneous neck dissection between 1999 and 2006 at our facility were retrospectively reviewed. Results: We analyzed 408 patients, including 33 patients with and 375 patients without SMG preservation. The 5-year disease-free and overall survival rates were 78.8% and 90.9% for the patients with SMG preservation and 75.4% and 90.4% for the patients without SMG preservation, and these differences were not statistically significant (P = 0.79, P = 0.99, respectively). Similar survival rates between patients with and without SMG preservation were observed in those with oral tongue squamous-cell carcinoma (SCC) and with buccal SCC. Patients with T2 OSCC with SMG preservation had significantly lower 5-year disease-free survival rate than those without SMG preservation (P = 0.02), but overall survival rates were similar between these two groups. Conclusions: Preservation of the SMG during neck dissection may be oncologically safe in patients with T1 OSCC, but the feasibility of SMG preservation seems less clear for T2 OSCC. ? 2010 Society of Surgical Oncology.[SDGs]SDG3adult; aged; article; cancer patient; cancer staging; cancer surgery; cancer survival; controlled study; disease free survival; early cancer; feasibility study; female; gingiva tumor; hard palate tumor; human; lip tumor; major clinical study; male; mouth carcinoma; neck dissection; oral squamous cell carcinoma; overall survival; retrospective study; submandibular gland; surgical approach; survival rate; tongue carcinoma; tongue squamous cell carcinoma; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Feasibility Studies; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Mouth Neoplasms; Neck Dissection; Neoplasm Staging; Retrospective Studies; Submandibular Gland; Survival Rate; Treatment Outcome; Young Adultjournal article10.1245/s10434-010-1294-7208390682-s2.0-79951552588