Yang, XiaomingXiaomingYangShi, QianQianShiLai, Chin-YuChin-YuLaiChen, Chi-YuanChi-YuanChenOhkoshi, EmikaEmikaOhkoshiYang, Shuenn-ChenShuenn-ChenYangWang, Chih-YaChih-YaWangBastow, Kenneth FKenneth FBastowWu, Tian-ShungTian-ShungWuPan, Shiow-LinShiow-LinPanCHE-MING TENGPAN-CHYR YANGLee, Kuo-HsiungKuo-HsiungLee2023-01-062023-01-062012-08-090022-2623https://scholars.lib.ntu.edu.tw/handle/123456789/626959Various E-ring hydroxylated antofine and cryptopleurine analogues were designed, synthesized, and tested against five human cancer cell lines. Interesting structure-activity relationship (SAR) correlations were found among these new compounds. The most potent compound 13b was further tested against a series of nonsmall cell lung cancer (NSCLC) cell lines in which it showed impressive antiproliferative activity. Mechanistic studies revealed that 13b is able to down-regulate HSP90 and β-catenin in A549 lung adenocarcinoma cells in a dose-dependent manner, suggesting a potential use for treating hedgehog pathway-driven tumorigenesis.enPHENANTHROINDOLIZIDINE ALKALOIDS PERGULARININE; PHENANTHROQUINOLIZIDINE ALKALOIDS; THYMIDYLATE SYNTHASE; BIOLOGICAL-ACTIVITY; ANTICANCER AGENTS; CELL-GROWTH; TYLOPHORINIDINE; INHIBITION; PROTEIN; TYLOCREBRINE[SDGs]SDG3journal article10.1021/jm3001218228235142-s2.0-84864960006WOS:000307264100009https://scholars.lib.ntu.edu.tw/handle/123456789/523592