國立臺灣大學醫學院復健科陳思遠2006-07-262018-07-132006-07-262018-07-132002-10-31http://ntur.lib.ntu.edu.tw//handle/246246/28966疾病預防與健康促進為近年來醫學界努力的重點。運動有益健康，研究老人 的日常活動量與健康的關係，更成為學者研究之重要問題。近年來的流行病學研 究的結果支持多從事運動可減少心血管疾病與腦中風的發生，學者一般都相信是 與血壓、膽固醇、血糖與體重的控制有關。除此之外，運動對於血小板功能、凝 血及纖維蛋白溶解系統等的影響，也是備受學者討論的可能機制。文獻上已有許 多探討運動與血小板功能及血中纖維蛋白原濃度的研究，但研究結果卻並不一致 而眾說紛紜，且罕有以老人為主要研究對象之研究報告。本研究之目的是想探討 老年人日常活動量對於血小板功能與血中纖維蛋白原濃度的作用，並進一步研究 不同性別中，日常活動量對於血小板功能與血中纖維蛋白原濃度的作用是否不 同。研究對象擬篩選在民國85 年參加「臺大醫院健檢」的1002 位台北市中正區 老人，邀請無心血管疾病或是其他重大疾病病史、未服用影響血小板功能藥物的 健康老人參加。結果共有80 位男性完成本研究，平均年齡為77±4 歲，根據受 試者日常活動量大小將其較少運動的20 人(四分之一)分類為缺乏運動組，其他 60 人則分類為規律運動組。比較兩組老人的檢查結果發現其年齡與血中纖維蛋 白原濃度並無差異(P > 0.05)，但規律運動組的老年男性之血小板凝集功能則低於 缺乏運動組。本研究結果支持老年人可經由規律運動來改善其血小板凝集功能， 並可能進一步減少其心血管疾病的發生；然而在本研究中，此相關並未達統計上 有意義。Physical activity or exercise has been proved beneficial for health. The relation between physical activities and health is becoming an important issue to be investigated among the elderly. Many epidemiological studies revealed that exercise reduces the mortality of cardiovascular diseases or stroke. Most researchers attributed the effect of exercise to the improved profiles in blood pressure, glucose metabolism, blood lipids, and weight control. However, exercise might have an effect on the platelet function, coagulation, or fibrinolysis system. There have been many studies evaluating the effect of exercise or physical activity on platelet function or plasma fibrinogen concentrations in literatures. These results were conflicting with each other and impossible to draw a conclusion currently. Few studies were performed among the elderly. The purpose of this study is to study the effect of physical activity on platelet function and plasma fibrinogen concentrations in the elderly. Predictive factors responsible for the platelet count, plasma fibrinogen concentrations, and platelet aggregation function will be explored also. Study subjects will be recruited from a cohort of 1002 elderly persons who lived in Chung-Cheng District of Taipei 3 City and received comprehensive medical exam in National Taiwan University Hospital in 1996. Subjects without a past history of cardiovascular diseases and anti-platelet medication will be invited to take part in this study. A total of 80 older men (mean age 77 years old) finished the assessments including “Modified Baecke Questionnaire (Chinese Version)”, platelet count, plasma fibrinogen concentrations, and platelet aggregation function. Subjects with the lowest quartile of physical activity score were classified as sedentary, and the others were active. There was no significant difference in age, height, weight, blood pressure, platelet count, and plasma fibrinogen concentrations between the two groups. Borderline significant difference was observed in ADP50, defined as the concentration with 50% response of platelet aggregation. The effects of physical activity on platelet count, plasma fibrinogen concentrations, and platelet aggregation function were not found in Spearman’s correlation analyses. Findings of this study might provide evidence to recommend the elderly to increase the amount of daily physical activities or participate in exercise regularly. However, the association of physical activity level with platelet function among older adults in this study was not conclusive.application/pdf163239 bytesapplication/pdfzh-TW國立臺灣大學醫學院復健科老人日常活動量纖維蛋白原血小板功能agedphysical activityfibrinogenplatelet function[SDGs]SDG3otherhttp://ntur.lib.ntu.edu.tw/bitstream/246246/28966/1/902314B002306.pdf