2021-06-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/691294"根管治療目的為移除根管內發炎的牙髓組織及細菌，來阻止牙根尖發炎。由於根管系統是一個極複雜的結構，因此要把根管內部的感染源移除是非常困難的。許多研究指出，現今任何根管沖洗方式都無法進行根管的完全清創，但根管清潔的程度是影響根管治療成功率最重要的因素，所以發展更有效的根管沖洗方式是值得更深入研究的。本研究計畫欲研發不同震盪頻率、器械材質和幾何外型設針的新式牙科超音波器械，達到更有效的根管清創效果。 本計畫預計執行三年，第一年本團隊將研發可調整頻率及功率等參數之牙科超音波控制系統，篩選具潛力的參數並自製新式超音波沖洗器械；並探討在不同沖洗液中使用自製新式超音波沖洗器械的震盪模式與其產生微流和穴蝕效應的能力。第二年探討自製新式超音波沖洗器械對於不同彎曲根管的殘屑移除能力，並以3D列印技術製作口外假牙模型，進行側枝根管浸潤能力測試。第三年則以人體口外真牙測試自製新式超音波沖洗器械對殘屑的清除、牙本質小管浸潤程度與經根管修磨後產生之塗抹層的移除能力，並以動物實驗檢測此新式超音波沖洗器械在活體上之有效性及安全性。 本研究成果預期能達到比傳統方法更佳的根管清創效果，在臨床上將有極大的潛力。" "Endodontic treatment aims to prevent apical periodontitis by removing inflammatory pulp tissue and bacteria in the root canal system. Because of the complex anatomical variation of the root canal system, it is difficult to eliminate the debris and infection inside. Many studies have indicated that current irrigation methods couldn`t achieve complete decontamination of the root canal system. However, cleansing of the root canal system is the most critical factor in endodontic treatment success. Therefore, develop a more efficient irrigation method is a crucial and urgent issue. This study is intended to develop novel dental ultrasonic irrigation instruments for more effective root canal cleansing by favorable vibration frequencies, materials, and geometries of the instruments. The study is planned for three years. First-year: 1. To develop a frequency adjustable dental ultrasonic control system for optimizing the parameters of dental ultrasonic irrigation instruments. 2. To customize novel dental ultrasonic irrigation instruments with various parameters to achieve higher cleansing efficacy. 3. To investigate the oscillation characteristics and ability to initiate microstreaming and cavitation generated from the customized developed novel dental ultrasonic irrigation instruments. Second-year: 1. To investigate debris removal efficacy of the developed novel dental ultrasonic irrigation instruments in the simulated various curved root canals. 2. Create simulated root canal system models with 3D printing 3. To investigate the lateral canal infiltration capability of developed novel dental ultrasonic irrigation instruments in simulated root canal system model. Third-year: 1. To investigate the capability of debris removal and dentinal tubule infiltration of developed novel dental ultrasonic irrigation instruments in extracted human teeth. 2. To investigate the removal capability of the smear layer found on root canal walls after root canal instrumentation from developed novel dental ultrasonic irrigation instruments in extracted human teeth. 3. To ensure the safety and effectiveness of the developed novel dental ultrasonic irrigation instruments with animal studies. This study`s outcome will have great potential to be used clinically by improving the cleansing efficacy for root canal treatment."超音波沖洗根管治療微流穴蝕效應ultrasoundirrigationendodontic treatmentmicrostreamingcavitation