PEI-LUNG CHENFann C.S.-J.Chang C.-C.Wu I.-L.WEI-YIH CHIULin C.-Y.WEI-SHIUNG YANGTIEN-CHUN CHANG2020-06-012020-06-0120070300-0664https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247860724&doi=10.1111%2fj.1365-2265.2007.02787.x&partnerID=40&md5=8842d9c00928343e8d4124c28d665af7https://scholars.lib.ntu.edu.tw/handle/123456789/495443Objective: To investigate whether markers in the candidate chromosome regions, including the human leucocyte antigen (HLA) region, are linked to Graves' disease (GD). Design: A familial linkage study with a candidate region approach. Patients: A total of 536 individuals in 122 multiplex Chinese-Han families with a GD proband and at least one other affected sibling, resulting in 270 affected sib-pairs. Subjects with a family history of noniatrogenic hypothyroidism or Hashimoto's thyroiditis were excluded. Measurements: We genotyped eight short tandem repeat polymorphism (STRP) markers in a 13.7 cM region covering the HLA region on chromosome 6p21 and 26 STRPs in four other candidate regions previously reported in the literature. Results: Multipoint nonparametric linkage (NPL) analysis showed significant linkage to the HLA region [the marker UniSTS:239159, nonparametric log of odds (LOD) score 3.44, P = 0.00003; NPL Z-score 4.1, P = 0.00002] from 270 affected sib-pairs. The 1-LOD support interval comprised the whole HLA region (ca. 4 Mb). By contrast, the maximal NPL Z-scores of the markers of the other candidate regions (2q33, 5q31, 7q22 and 14q31) previously reported were all less than 1.0. Conclusions: Our results provide strong support for linkage of GD to the HLA region. Further dissection of this region to identify the candidate gene for GD is warranted in our population. ? 2007 The Authors.[SDGs]SDG3biological marker; article; Chinese; chromosome 14q; chromosome 2q; chromosome 5q; chromosome 6p; chromosome 7q; controlled study; familial disease; family history; female; genetic association; genetic linkage; genetic polymorphism; genotype; Graves disease; Hashimoto disease; HLA system; human; hypothyroidism; iatrogenic disease; major clinical study; male; nonparametric test; priority journal; scoring system; short tandem repeat; sibling; Taiwan; Asian Continental Ancestry Group; Chromosome Mapping; Female; Genetic Markers; Genetic Predisposition to Disease; Graves Disease; Humans; Linkage (Genetics); Lod Score; Major Histocompatibility Complex; Male; Microsatellite Repeats; Taiwanjournal article10.1111/j.1365-2265.2007.02787.x174929522-s2.0-34247860724