TSO-TING LAIChen S.-N.CHUNG-MAY YANG2021-03-222021-03-2220160721-832Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84961202329&doi=10.1007%2fs00417-015-3133-9&partnerID=40&md5=ddf3382a161801b56dd98fbc74316f68https://scholars.lib.ntu.edu.tw/handle/123456789/554476Purpose: To report the clinical findings and surgical outcomes of lamellar macular holes (LMH) with or without lamellar hole-associated epiretinal proliferation (LHEP), and those of full-thickness macular holes (FTMH) presenting with LHEP. Methods: From 2009 to 2013, consecutive cases of surgically treated LMH, and all FTMH cases with LHEP were reviewed, given a follow-up time over 1?year. Results: In the LMH group (43 cases), those with LHEP (19 cases) had significantly thinner bases and larger openings than those without (24 cases). The rate of disrupted IS/OS line was higher in the LHEP subgroup preoperatively (68.4?% vs 37.5?%), but similar between subgroups postoperatively (36.8?% and 33.3?%). The preoperative and postoperative visual acuity showed no significant difference between two subgroups. In the FTMH group (13 cases), the average hole size was 219.2 ± 92.1?μm. Permanent or transient spontaneous hole closure was noted in 69.2?% of cases. An intact IS-OS line was found in only 23?% of cases at the final follow-up. Conclusion: In the LMH group, LHEP was associated with a more severe defect but didn’t affect surgical outcomes. In the FTMH group, spontaneous hole closure was frequently noted. Despite small holes, disruption of IS-OS line was common after hole closure. ? 2015, Springer-Verlag Berlin Heidelberg.[SDGs]SDG3adult; aged; Article; clinical article; disease severity; epiretinal membrane; female; full thickness macular hole; human; lamellar hole associated epiretinal proliferation; male; optical coherence tomography device; postoperative period; preoperative period; priority journal; retina macula hole; spectral domain optical coherence tomography; treatment outcome; visual acuity; basement membrane; classification; clinical trial; epiretinal membrane; middle aged; multicenter study; optical coherence tomography; pathology; pathophysiology; physiology; prone position; Retinal Perforations; retrospective study; very elderly; vitrectomy; young adult; Adult; Aged; Aged, 80 and over; Basement Membrane; Epiretinal Membrane; Female; Humans; Male; Middle Aged; Prone Position; Retinal Perforations; Retrospective Studies; Tomography, Optical Coherence; Visual Acuity; Vitrectomy; Young Adultjournal article10.1007/s00417-015-3133-9263112572-s2.0-84961202329