Lin K.-W.Huang A.-M.Yang S.-C.Weng J.-R.Hour T.-C.YEONG-SHIAU PULin C.-N.2021-02-022021-02-0220120308-8146https://www.scopus.com/inward/record.uri?eid=2-s2.0-84863982260&doi=10.1016%2fj.foodchem.2012.04.133&partnerID=40&md5=fc6736a23953da5a51419686976794a9https://scholars.lib.ntu.edu.tw/handle/123456789/544402Two new triterpenoids, garcinielliptones Q (1) and S (3), and a new phloroglucinol, garcinielliptone R (2), were isolated from the seed of Garcinia subelliptica. Their structures were established by analysis of their spectroscopic data. Phloroglucinol, garcinielliptone FC (4) from this plant exhibited a significant increase of antiproliferative effect, while 4 combined with cisplatin significantly caused decrease of cell inhibition induced by cisplatin in NTUB1. Exposure of NTUB1 cells to 4 cotreated with cisplatin for significantly decreased the amount of reactive oxygen species (ROS) than that of the total amount generated by 4 and cisplatin. These results suggested that 4 could protect the cisplatin toxicity through reduction of ROS in NTUB1. Phloroglucinols, garcinielliptones, A (5) and F (7), and garsubelline A (6), from this plant, revealed ABTS radical cation scavenging activity and 5 displayed an inhibitory effect on xanthine oxidase. These finding showed that 5-7 may be used as antioxidants. ? 2012 Elsevier Ltd. All rights reserved.Antioxidant; Cytotoxity; Garcinia subelliptica; Phloroglucinol; Triterpenoid[SDGs]SDG3Antioxidant; Cytotoxity; Garcinia subelliptica; Phloroglucinol; Triterpenoids; Hydrogen storage; Platinum compounds; antioxidant; cisplatin; cytotoxic agent; garcinielliptone A; garcinielliptone F; garcinielliptone FC; garcinielliptone Q; garcinielliptone R; garcinielliptone s; garsubelline A; reactive oxygen metabolite; unclassified drug; xanthine oxidase; antioxidant activity; article; cancer cell; cell proliferation; controlled study; cytotoxicity; drug potentiation; drug structure; Garcinia; Garcinia subelliptica; human; human cell; Antioxidants; Cell Death; Cell Line, Tumor; Cytotoxins; Garcinia; Humans; Plant Extracts; Seeds; Garcinia subellipticajournal article10.1016/j.foodchem.2012.04.133228681692-s2.0-84863982260