LING-HUNG WEIChou C.-HSu J.-L.2020-02-122020-02-122004https://scholars.lib.ntu.edu.tw/handle/123456789/458253The use of photodynamic therapy (PDT) that is considered as a promising treatment in the clinic for use in oncology was discussed. PDT requires three elements mainly light, a photosensitizer and oxygen. It was found that PDT could transcriptionally induce or enhance hypoxia-inducible factor - 1α (HIF-1α) expression in different cervical cancer cell lines, immortalized cervical epithelium cell line 183A and human umbilical vein endothelial cells (HUVEC). PDT activated HIF - 1α protein expression was markedly inhibited and subsequently sensitized SiHa cells to PDT. The results provided important information to improve the therapeutic efficacy and had great clinical applicable potential.[SDGs]SDG3Bioassay; Blood; Cells; Diseases; Genes; Light emitting diodes; Oncology; Patient monitoring; Photosensitizers; Physiological models; Tissue; Tumors; Cancer cells; Endothelial cells; Gene activation; Human umbilical vein endothelial cells (HUVEC); Microvascular injury; Photodynamic therapyconference paper2-s2.0-20844458790