內科CHANG, SHAN-CHWENSHAN-CHWENCHANGCHEN, YEE-CHUNYEE-CHUNCHENLUH, KWEN-TAYKWEN-TAYLUHHSIEH, WEI-CHUANWEI-CHUANHSIEH2008-12-052018-07-112008-12-052018-07-111997http://ntur.lib.ntu.edu.tw//handle/246246/88416The in vitro susceptibility to 9 β-lactam antibiotics of 65 clinical strains ofStreptococcus pneumoniae collected from a teaching hospital in Taiwan during the period from 1989 to 1994 were studied. Minimum inhibitory concentrations (MIC) were determined by the agar dilution method with 5% horse blood. Intermediate resistance to penicillin G was found in 24.6% of the strains (MIC, 0.125 to 1 μg/mL) and 7.7% of the strains were fully-resistant to penicillin G (MIC, 2 μg/mL). Ten strains (15.4%) were fully-resistant to cefotaxime (MIC, ≥2 μg/mL), whereas 3 strains (4.6%) showed intermediate resistance (MIC 1 μg/mL). The intermediate- and fully-resistant rates for penicillin increased from 12.5% and 0% in the period 1989 to 1991 to 27 .3% and 22.7% in 1994, respectively. The rate of strains intermediately- and fully-resistant to cefotaxime increased from 0% in the period 1989 to 1991 to 9.1% and 22.7% in 1994 , respectively. There was also a high probability of resistance to cefotaxime in strains that were intermediately - or fully-resistant to penicillin G.en-USStreptococcus pneumoniaesusceptibilitypenicillin resistancebeta-lactam antibiotics