Department of Chemistry, National Taiwan UniversityBabu, GovindarajuluGovindarajuluBabuYu, Hui-MingHui-MingYuYang, Shyh-MingShyh-MingYangFang, Jim-MinJim-MinFang2006-11-152018-07-102006-11-152018-07-102004http://ntur.lib.ntu.edu.tw//handle/246246/2006111501232963The SmI2-promoted three-component coupling reaction of thiophene-2-carboxylate, indole-2-carbaldehyde & acetophenone provides an expedient route to a series of tetracyclic carbazolothiophene compounds bearing the indole & thiophene rings. Among these samples, 9-benzyl-4-methyl-4-(4-hydroxyphenyl)-10-oxo-4,10-dihydrocarbazolo[2,3-b]thiophene-2-carboxylic acid (18) shows the most potent inhibition against the endothelin-1 induced increase of intracellular calcium ion concentration.application/pdf174023 bytesapplication/pdfzh-TWCoupling reactionsEndothelinSamarium diiodideThio-pheneIndole[SDGs]SDG6journal article10.1016/j.bmcl.2003.12.067http://ntur.lib.ntu.edu.tw/bitstream/246246/2006111501232963/1/5619.pdf