Chen, M.-H.M.-H.ChenJenh, Y.-J.Y.-J.JenhWu, S.-K.S.-K.WuChen, Y.-S.Y.-S.ChenHanagata, N.N.HanagataFENG-HUEI LIN2020-02-262020-02-262017https://scholars.lib.ntu.edu.tw/handle/123456789/463886The use of photodynamic therapy (PDT) in the treatment of brain cancer has produced exciting results in clinical trials over the past decade. PDT is based on the concept that a photosensitizer exposed to a specific light wavelength produces the predominant cytotoxic agent, to destroy tumor cells. However, delivering an efficient light source to the brain tumor site is still a challenge. The light source should be delivered by placing external optical fibers into the brain at the time of surgical debulking of the tumor. Consequently, there exists the need for a minimally invasive treatment for brain cancer PDT. In this study, we investigated an attractive non-invasive option on glioma cell line by using Tb3+-doped LaF3 scintillating nanoparticles (LaF3:Tb) in combination with photosensitizer, meso-tetra(4-carboxyphenyl)porphyrin (MTCP), followed by activation with soft X-ray (80?kVp). Scintillating LaF3:Tb nanoparticles, with sizes of approximately 25?nm, were fabricated. The particles have a good dispersibility in aqueous solution and possess high biocompatibility. However, significant cytotoxicity was observed in the glioma cells while the LaF3:Tb nanoparticles with MTCP were exposed under X-ray irradiation. The study has demonstrated a proof of concept as a non-invasive way to treat brain cancer in the future. ? 2017, The Author(s).Brain cancer; LaF3:Tb; Non-invasive; Photodynamic therapy; X-ray[SDGs]SDG3Biocompatibility; Cell culture; Cytotoxicity; Diseases; Doping (additives); Irradiation; Lanthanum compounds; Light sources; Nanoparticles; Optical fiber fabrication; Optical fibers; Photodynamic therapy; Photosensitizers; Scintillation; Solutions; Terbium compounds; Tumors; Brain cancer; Glioma cell lines; LaF3 nanoparticles; Minimally invasive treatments; Non-invasive; Photodynamic therapy (PDT); Tetra (4 carboxyphenyl)porphyrin; X ray irradiation; X raysjournal article10.1186/s11671-017-1840-32-s2.0-85010060303https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010060303&doi=10.1186%2fs11671-017-1840-3&partnerID=40&md5=11e5f71a9426c32e1ad2ef5c50f43d78