SHOEI-SHENG LEEChen W.-C.CHIH-FEN HUANGSu Y.2021-07-162021-07-1619981633864https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031763893&doi=10.1021%2fnp9800856&partnerID=40&md5=aee165fd2925a3e93b8c08ae53792641https://scholars.lib.ntu.edu.tw/handle/123456789/571504Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo- ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 μg/mL, respectively, and an IC50 of 11.3 μg/mL against normal cell line FS-5.[SDGs]SDG31 decarboxy 3 oxoceanothic acid; 1 norceanothane derivative; betulic acid; ceanothane; ceanothic acid derivative; unclassified drug; article; cancer cell culture; drug cytotoxicity; drug isolation; drug structure; hela cell; structure activity relation; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Norsteroids; Plants, Medicinal; Spectrophotometry, Infrared; Triterpenes; Tumor Cells, Culturedjournal article10.1021/np980085698341492-s2.0-0031763893