CHUN-PIN CHIANGHuang J.-S.Wang J.-T.Liu B.-Y.Kuo Y.-S.Hahn L.-J.YEN-PING KUO2021-07-052021-07-0519990904-2512https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033081344&doi=10.1111%2fj.1600-0714.1999.tb01999.x&partnerID=40&md5=97409f6dd6b7e1382a6c32b55388eefdhttps://scholars.lib.ntu.edu.tw/handle/123456789/569228Expression of p53 protein was examined in oral squamous cell carcinoma (SCC) from patients who were areca quid (AQ) chewers and/or tobacco smokers, using anti-p53 antibodies with an immunoperoxidase technique. Positive p53 stain was observed in 47 of 81 (58%) cases of oral SCC. p53 overexpression was found to be higher in patients without AQ chewing and smoking habits than in patients with these two habits (80% vs 52%, P=0.076). No significant correlation was found between p53 expression and the patients' age, sex, cancer location, clinical staging, primary tumor TNM status, or histological differentiation of SCC. The Kaplan-Meier analysis showed that the prognosis for patients with p53-negative tumors was significantly better than that for patients with p53-positive tumors (P<0.05). A significant correlation was also observed between positive lymph node status and poor prognosis (P<0.05). These results suggest that p53 may serve as an adjuvant marker of poor survival in patients with oral SCCs in Taiwan.Areca quid chewing; Oral squamous cell carcinoma; p53; Prognosis[SDGs]SDG3journal article10.1111/j.1600-0714.1999.tb01999.x99502532-s2.0-0033081344