林隆君2006-07-262018-07-112006-07-262018-07-112004http://ntur.lib.ntu.edu.tw//handle/246246/23664血膽固醇過高症與全身性動脈粥樣硬化相關聯。血膽固醇過高症對微循環的衝擊擾亂正 接受眾多的研究。在這一項研究中，我們使用了加量膽固醇飲食餵食兔子。動態的對比劑 增益磁共振影像顯示血膽固醇過高症和微循環表面區通透性的增加相關但是沒有影響心肌 血流。那些血膽固醇過高症的兔子病理結果描述 isolectin －或平滑肌－肌動蛋白的微血管 增加。而心肌層的微血管週邊和間質組織中 VEGF 的表達也出現。血膽固醇過高症不需要 造成顯著的灌流缺陷就增加冠狀動脈心肌微循環表面之通透性。其增加的微血管密度，或 外皮細胞參與了微血管的再塑形。 VEGF 可被視為一個可能的機制。Hypercholesterolemia (HC) is associated with atherosclerosis in systemic arteries. Its impacts on microcirculatory disturbances are receiving rigorous investigations. In this study, we used the cholesterol-enrich diet to treat the rabbit. The dynamic contrast-enhanced magnetic resonance imaging showed that the induced hypercholesterolemia was associated with increase in permeability surface area product but did not influence the myocardial blood flow. The pathological examination of those hypercholesterolemic rabbits delineated greater density of isolectin- and smooth muscle α -actin bound microvessels. Patchy expression of VEGF in perivascular and interstitial space of myocardium was also noted. Hypercholesterolemia was associated with increased coronary leakage without evident perfusion defect. Increased microvessel density, either pericyte-bound or not, suggested microvascular remodeling. VEGF could be induced in the setting and served as a possible underlying mechanism.application/pdf136885 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科Dynamic contrast-enhanced magnetic resonance imagingHypercholesterolemiaMicrocirculatory permeabilityVEGFreporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23664/1/922314B002324.pdf