YEN-WEN WUHo, Sing KongSing KongHoTseng, Wei-KungWei-KungTsengYeh, Hung-IHung-IYehLeu, Hsin-BangHsin-BangLeuYin, Wei-HsianWei-HsianYinLin, Tsung-HsienTsung-HsienLinChang, Kuan-ChengKuan-ChengChangWang, Ji-HungJi-HungWangCHAU-CHUNG WUChen, Jaw-WenJaw-WenChen2021-03-112021-03-1120202045-2322https://scholars.lib.ntu.edu.tw/handle/123456789/551596This study aimed to investigate the prognostic value of high-sensitivity creatine kinase-myocardial band or fraction (hsCK-MB) in comparison with other well-established biomarkers including heart type-fatty acid binding protein (H-FABP) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with stable coronary heart disease (SCHD). A total of 1,785 patients were enrolled and followed for 36 months. The primary outcome was all-cause mortality. The secondary outcomes included cardiovascular (CV) death, acute myocardial infarction (AMI), angina-related hospitalizations, and hospitalizations for heart failure. The all-cause mortality rate was significantly higher in the high hsCK-MB group compared to the low hsCK-MB group (4.64% vs. 1.88%, p = 0.0026). After adjusting for baseline covariates, there were no significant differences for the secondary outcomes. H-FABP (≥4.226 ng/mL) was the best predictor for all-cause mortality (HR = 2.68, 95% CI = 1.28-5.62, p = 0.009) and CV death (HR = 6.84, 95% CI = 1.89-22.14, p = 0.003). The high NT-proBNP group had a higher AMI-related hospitalization rate (HR = 1.91, 95% CI = 1.00-3.65, p = 0.05). Neither the addition of hsCK-MB to any other markers nor combinations of the three markers improved the prognostic significance of CV outcomes. In conclusion, hsCK-MB was an independent predictor for all-cause mortality but not CV outcomes in patients with SCHD. Combination of hsCK-MB, H-FABP and NT-proBNP failed to improve the prognostic power for all-cause mortality or CV outcomes.animationBAND ISOENZYME ELEVATION; CK-MB; TROPONIN-I; PROGNOSTIC VALUE; MORTALITY; EVENTS[SDGs]SDG3biological marker; creatine kinase MB; fatty acid binding protein; adult; coronary artery disease; female; follow up; heart failure; heart infarction; hospitalization; human; male; metabolism; mortality; prognosis; Adult; Biomarkers; Coronary Disease; Creatine Kinase, MB Form; Fatty Acid-Binding Proteins; Female; Follow-Up Studies; Heart Failure; Hospitalization; Humans; Male; Myocardial Infarction; Prognosisjournal article10.1038/s41598-020-61894-3322213372-s2.0-85082539163WOS:000560408800017https://scholars.lib.ntu.edu.tw/handle/123456789/516256https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082539163&doi=10.1038%2fs41598-020-61894-3&partnerID=40&md5=8024a3844b1c3d705406d6c7103b1c06