廖朝崧2006-07-262018-07-112006-07-262018-07-112003http://ntur.lib.ntu.edu.tw//handle/246246/23603高三酸甘油酯血症在中國人是相當常見的血脂異常，過去對於三酸甘油酯與動脈硬化 的關係有諸多爭議，但近年來已認為三酸甘油酯是動脈硬化的一個獨立危險因子。高三酸 甘油酯血症同時也是新陳代謝症候群的一個主要角色。富含三酸甘油酯的脂蛋白在人類具 有高度誘發動脈硬化之作用。本研究探討高三酸甘油酯血症對單核細胞粘附作用及內皮細 胞功能之影響。一共有90 位病人進行122 次試驗，其中30 人進行2 次試驗。結果發現， 經治療後病人的血脂都有明顯改變，三酸甘油酯明顯下降，高密度脂蛋白膽固醇明顯上升。 單核細胞粘附作用並未受三酸甘油酯所影響，但與低密度酯蛋白膽固醇有關。三酸甘油酯 過高病人其內皮細胞功能變差，但經治療，三酸甘油酯下降後則內皮細胞功能恢復。總結 之，三酸甘油酯並非決定單核細胞粘附作用之重要因素，但低密度脂蛋白膽固醇則是。高 三酸甘油酯血症可明顯造成內皮細胞功能失常，此一失常在三酸甘油酯改善後可以獲得改 善。Hypertriglyceridemia is a very common lipid disorder in Chinese. The role of high serum triglyceride (TG) in atherosclerosis has been controversial for a long time, but recently it has been widely accepted that TG is definitely an independent risk factor for atherosclerosis. Hypertriglyceridemia is one important component of metabolic syndrome. TG-rich lipoproteins have been identified highly atherogenic in humans. We studied the effects of hypertriglyceridemia on in vitro mononuclear cell adhesion to cultured human endothelial cells and the in vivo endothelial function by using brachial artery flow mediated dilatation method. A total of 90 patients with 122 tests were completed. Thirty patients had 2 studies. We found that after intervention the patients had their lipid profile markedly changed with reduction of TG and increase of HDL-C. The mononuclear cell adhesion was found not correlated with serum TG level but could be affected by LDL-C level. Patients with high TG levels had impaired endothelial function which was found improved after reduction of the serum TG levels. It was concluded that TG was not an important factor in determining the adhesion of mononuclear cells to endothelial cells but LDL-C was. Hypertriglyceridemia could significantly affect the endothelial function through impairment of flow-mediated vasodilatation.application/pdf56409 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科高三酸甘油酯血症動脈硬化糖尿病低密度脂蛋白低密度脂蛋白細分類高密度脂蛋白高密度脂蛋白細分類內皮細胞功能hypertriglyceridemiaatherosclerosisdiabetes mellituslow density lipoproteinlow density lipoprotein subclasshigh density lipoproteinhigh density lipoprotein subclassendothelial function[SDGs]SDG3reporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23603/1/912314B002282.pdf