盛望徽2006-07-262018-07-112006-07-262018-07-112005http://ntur.lib.ntu.edu.tw//handle/246246/23689We studied the chlorhexidine susceptibility, molecular typing, and the distribution of the qacA/B gene of methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained in 1990, 1994, 1995, and 2002 at the National Taiwan University Hospital (NTUH). The prevalence rate of MRSA with a high minimum inhibitory concentration (MIC) of chlorhexidine (≧4 μ g/mL) was found to increase rapidly during this 13-year period, from 3.3% in 1990 to 66.7% in 2002. Nearly all of the MRSA isolates with high chlorhexidine MICs carried the qacA/B gene and belonged to a single molecular type. The prevalence rate of MRSA isolates with high chlorhexidine MIC correlates well with that of MRSA isolates belonging to the molecular type. We conclude that the prevalence rate of MRSA with high chlorhexidine MIC increased rapidly during past 13 years at the NTUH, which was associated with an endemic strain, carrying the qacA/B gene, spreading in the hospital.application/pdf157874 bytesapplication/pdfzh-TW國立臺灣大學醫學院內科methicillin-resistant Staphylococcus aureusMRSAchlorhexidinepulsed-field gel electrophoresisqacA/Breporthttp://ntur.lib.ntu.edu.tw/bitstream/246246/23689/1/932314B002080.pdf