2020-01-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/674892摘要：由於目前大多數氫氧基磷灰石(hydroxyapatite)皆為高溫製程且結晶性過好，造成應用於骨骼修復材料時，由於降解時間較長而無法達到理想生物降解時間，本實驗將結合中研院生醫應用完料需求設計上的優勢，以及台大化工系在材料製備、製程優化及產量放大上的實力，由於鎂用於骨修復材料可以加速生物降解的時間，並且增加生物相容性，故開發以常溫製程並利用新穎的磷脂質及仿生細胞膜合成技術，製備不同比例含鎂量之氫氧基磷灰石，應用於骨骼修復材料，此技術的優點為仿生條件下利用室溫製成，且合成方法可製備出含有機質之複合材料，且合成成本低。此外中研院張瑛芝研究員與史丹佛大學合作中，具有在基質上有效控制合成之雙層之技術，計畫願景為研發一個可大量生產，能快速修復骨骼且具有高度生物相容性的骨骼材料。<br> Abstract: As hydroxyapatite (HAP) and tricalcium phosphate (&#61538;-TCP) have excellent biocompatibility, biological activity and bone conduction properties, they have been widely used as the bone repairing materials. The actual structure of inorganic substance in the human bone is a poor crystalline hydroxyl apatite, however, the HAP synthesized in general commercial products is a highly crystalline sintered powder. From the perspective of the current field of biomedical materials, HAP has a high potential for the application. Early research on the establishment of material properties will accelerate the process of practical application of calcium phosphate materials.仿生智能材料細胞分離微流體淨化和維護Biomimetic smart materials and interfaceRare cell isolationpurification and maintenance by smart surfaces and microfluidics