2013-08-012024-05-14https://scholars.lib.ntu.edu.tw/handle/123456789/658218摘要：本三年研究計劃除延續觀察離心運動對肌腱機械特性與微循環(microcirculation)的急性效應，並以神經機械學(neuromechanics) 的角度，分析最大等速離心運動對下肢肌腱的機械特性與微循環之影響。在第一年研究中將驗證最大膝關節伸直離心收縮次數是否與髕骨肌腱機械特性，以及肌腱中段微循環(包含血紅素總量與肌腱血氧化飽和程度)之改變量有關，以及在最大膝關節離心收縮中加入預防性治療介入後，是否能減少或減緩最大離心收縮對髕骨肌腱機械特性以及肌腱微循環之負面影響，並在第二年將分析物理治療因子(包含超音波、干擾波電療、震動，以及低能雷射等)，對阿基里氏肌腱中段微循環之影響，以及在第三年觀察接受單側阿基里氏腱修補的患者，在術後三個月以內肌腱中段微循環與第三、六個月肌腱的機械特性，和爆發性與平衡表現之相關性。本三年計畫企圖一、確認離心收縮次數為影響肌腱機械特性與微循環之外在因子，及預防性介入可減緩離心收縮對肌腱機械特性及肌腱微循環之作用，以及二、將物理治療因子對微循環之療效做出分類，三、觀察阿基里氏腱修補後肌腱微循環是否與後續機械特性有關。以決定在預防、治療肌腱傷害與接受肌腱修補手術後，應使用何種運動介入或物理治療因子，促進肌腱癒合以及下肢運動功能。<br> Abstract: Tendinopathy characterized by overuse and overloading is a common injury in athleticpopulations. Eccentric contraction is believed as an extrinsic risk factor to acute or chronictendinopathy. Adverse effects of acute eccentric contractions on the tendon, includingdecrease mechanical properties and increase microcirculation, may jeopardize the tendon andlead to a following tendinopathy. The objectives of this three-year research project are 1-1) toinvestigate effects of repetitions of maximal eccentric contractions of knee extension onmechanical properties (tendon stiffness) and microcirculation (total hemoglobin and oxygensaturation) of the patellar tendon. Furthermore, correlations between changes of themechanical properties and microcirculation are analyzed; 1-2) to study effects of intervalintervention during the eccentric contractions on the tendon properties and microcirculation; 2)to evaluate the effects of physical agents on microcirculation of the Achilles tendon; 3) toelucidate the microcirculation of the early stage of repaired Achilles tendon. In addition,correlation between microcirculation results of early stage and the mechanical properties inthe late stage after repair surgeries are assessed.In the first year, 45 male subjects, aged from 20 to 45 years old, are going to be recruitedand randomized assigned into three groups (4sets of 60 repetitions at a speed of 60 degree persecond, 4 sets of 80 repetitions at a speed of 60 degree per second, and 4sets of 80 repetitionswith intervention) to determine whether the repetitions of maximal eccentric contractionshave significant effects on the tendon properties and microcirculation in their dominant leg. Inaddition, whether the effects of the maximal eccentric contractions can be attenuated byprophylactic intervention, such as submaximal isometric contraction, between sets of theeccentric contractions is also investigated. In the second year, effects of physical modalities(including ultrasound, low power laser, interferential current and vibration) on the tendonmicro-circulation in the Achilles tendon in both (dominant and non-dominant sides) legs areinvestigated in subjects, aged from 20 to 45 years old. These modalities are applied on themiddle portion of the Achilles tendon or muscle belly of the calf muscles, and the tendonmicrocirculation is measured before and after the applications. In the third year, 20 malesubjects with a unilateral Achilles repair are going to be recruited. Microcirculation will beassessed in the 1st, 2nd and 3rd month after the repair. Furthermore, tendon mechanicalproperties and functional performances are assessed in the 3rd and 6th month after the repair.Results of this current study are going to 1) confirm the effects of repetitions of maximaleccentric contractions on tendon mechanical properties and microcirculation in the patellartendon; 2) confirm there is a correlation between acute changes of tendon mechanicalproperties and microcirculation; 3) assess prophylactic effects of submaximal isometriccontraction within the maximal eccentric contractions; 4); determine the effects of physicalmodalities on microcirculation of the Achilles tendons; 5) elucidate the characteristics oftendon microcirculation early after Achilles repair (<3 month) and study correlations betweenmicrocirculation and mechanical properties in the late stage of repairs of tendon surgery.肌腱機械特性微循環離心收縮物理治療因子肌腱修補tendon mechanical propertymicrocirculationeccentric contractionphysical modalitytendon repair