Huang, C.-Y.C.-Y.HuangLiaw, C.-C.C.-C.LiawChen, B.-W.B.-W.ChenChen, P.-C.P.-C.ChenSu, J.-H.J.-H.SuSung, P.-J.P.-J.SungCHANG-FENG DAIChiang, M.Y.M.Y.ChiangSheu, J.-H.J.-H.Sheu2018-09-102018-09-102013http://www.scopus.com/inward/record.url?eid=2-s2.0-84886835950&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/378620Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of cancer cell lines also were determined. ? 2013 The American Chemical Society and American Society of Pharmacognosy.[SDGs]SDG3[SDGs]SDG14sinubrasolide A; sinubrasolide B; sinubrasolide C; sinubrasolide D; sinubrasolide E; sinubrasolide F; sinubrasolide G; unclassified drug; withanolide; article; cancer cell culture; carbon nuclear magnetic resonance; coral; drug acetylation; drug cytotoxicity; drug isolation; drug structure; nonhuman; proton nuclear magnetic resonance; Sinularia brassica; X ray crystallography; Animals; Anthozoa; Antineoplastic Agents; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HT29 Cells; Humans; K562 Cells; Leukemia P388; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Withanolidesjournal article10.1021/np400454q2-s2.0-84886835950WOS:000326319700012