Aldosterone-producing adenoma-harbouring KCNJ5 mutations is associated with lower prevalence of metabolic disorders and abdominal obesity

Chen, Kuan-MingKuan-MingChenChang, Yu-LingYu-LingChangWu, Tung-HsinTung-HsinWuBO-CHING LEEPO-TING CHENKAO-LANG LIUHong, Jia-ShengJia-ShengHongCHIN-CHEN CHANGVIN-CENT WUYEN-HUNG LINTAIPAI Study Group2022-05-122022-05-1220210263-6352https://scholars.lib.ntu.edu.tw/handle/123456789/610508Aldosterone overproduction and lipid metabolic disturbances between idiopathic hyperaldosteronism (IHA) and unilateral aldosterone-producing adenoma (APA) have been inconsistently linked in patients with primary aldosteronism. Moreover, KCNJ5 mutations are prevalent among APAs and enhance aldosterone synthesis in adrenal cortex. We aimed to investigate the prevalence of metabolic syndrome (MetS) in each primary aldosteronism subtype and observe the role of KCNJ5 mutations among APAs on the distribution of abdominal adipose tissues quantified using computed tomography (CT), including their changes postadrenalectomy.enadrenalectomy; idiopathic hyperaldosteronism; KCNJ5 mutations; metabolic syndrome; unilateral aldosterone-producing adenoma; SOMATIC MUTATIONS; EXPRESSION; FREQUENT; RECEPTOR[SDGs]SDG3Aldosterone-producing adenoma-harbouring KCNJ5 mutations is associated with lower prevalence of metabolic disorders and abdominal obesityjournal article10.1097/HJH.0000000000002948343136322-s2.0-85121953306WOS:000714688200005