2009-08-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/663213摘要：心臟冠狀動脈(Coronary Artery Disease)退化及心肌退化症，往往會使患者過勞或進行一些劇烈活動時，引起心絞痛甚至造成患者死亡，已經成為國人十大死因之第二名。雖然近幾年來醫學上對於治療心血管疾病有相當之進步，但心臟衰竭之治療仍具有相當之挑戰性及極限，因此如何提供心衰竭患者全面性的照護，是刻不容緩的議題。其中，最為重要的即為心衰竭的長期及緊急照護之用藥，然而，用藥的效果及用量，會因為心衰竭病患基因之不同而有不同的感受性，因此，如何進一步利用DNA晶片技術進行檢驗及資料篩檢即成為心臟疾病相關早期預警及輔助用藥等生醫照護科技下一步重要的發展。 本研究團隊針對此一課題發展以標準半導體製程為基礎的DNA檢測晶片系統。本研究團隊計劃將以對DNA分子及元件表面處理的了解做為為基礎，利用對奈微米電子元件的知識為工具，先以元件理論分析的方式來建構此一DNA檢測晶片的基礎模型，而後以標準半導體製程技術進行DNA檢測晶片及其相關電路之設計及製作，進一步與臨床資料進行分析比對，期能使國內生物感測元件知識與技術可以確實與臨床治療技術更進一步的整合，並可藉由國內獨步全球之半導體製程技術將此一研究成果落實於生物科學之應用層面上，以提升既有之產業價值。 <br> Abstract: Coronary artery disease is one of the major fatal illnesses in Taiwan. It causes angina pectoris even death of the patients. The advancement of the medical treatment improves the coronary artery disease mortality; however, it is still a challenge to take care of the heart disease patient especially in emergency and chronic recovery. Among varies aspects, the medicine treatment is one of the treatment methods for the care of heart disease patients. The effect and the dose of the heart disease medicine treatment are highly dependent on personal DNA characteristics. Therefore, it is important to develop the DNA chip for heart failure disease analysis and related DNA information analysis for the heart failure disease early detection and medical assistance. With rapid advancements of System-On-Chip and MEMS/nanotechnologies, a wide variety of new chemical analysis devices and their integrated system, such as biomolecular analysis devices and micro-total-analysis systems, have been designed, implemented, and demonstrated. However, few of them integrated with clinical analysis and achieve the practical requirement of the modern biomolecular diagnosis. As the consequence, this research project will aim at the development of DNA analysis system-on-chip for the clinical heart-failure-medicine-treatment, which is one of the most important steps toward the heart failure disease treatment in both emergency and chronic recovery. In specific, this research project will be based on the basic understanding of electronic devices, biomolecular interaction, and nano/micro fabrication to design and implement the DNA chip for heart-failure medicine treatments. Furthermore, this research project will also compare with clinical data in order to bridge the electronics, bioinformatics, and clinical applications into a fully integrated system.CMOS生物分子感測器CMOS biosensor