周宏農2006-07-262018-07-062006-07-262018-07-062003-07-31http://ntur.lib.ntu.edu.tw//handle/246246/20559The integrated project was designed to explore bioactive nature products from marine microalgae, macroalgae and soft corals indigenous to Taiwan. One hundred and fifty three samples of macroalgae and 54 soft corals samples were collected, and more than 200 strains of microalgae were isolated and cultivated in the first year. In the previous screening, more than 20 % of the samples mentioned above were found to exert strong cytotoxicity. After that, twenty-six compounds were purified from microalgae, at least 6 of them exerted strong cytotoxicity, and 12 of them were new compounds, among which 2 new skeletal compounds were found. Fifty-five compounds were purified from macroalgae, nine of them exerted strong cytotoxicity, and 28 of them were new compounds, among which 14 new skeletal compounds were found. Eight-five compounds were purified from soft corals, eleven of them exerted strong cytotoxicity, thirty-five of them were new compounds, among which 2 new skeletal compounds were found, revealing the potential to approach the bioactive or new compounds from these marine creatures indigenous to Taiwan.本計畫針對台灣地區的海洋微細藻、大型藻及軟珊瑚進行抗癌及抗病毒活性天然物的 探勘。初期共計完成153 種大型藻、54 種軟珊瑚，及166 個微細藻、35 個紅藻或褐藻絲狀 體藻株的的採樣與培養；在初步的活性篩檢中，發現各大項樣品均有超過兩成具有顯著的 細胞毒殺活性。在後續化合物的純化、鑑定研究中，微細藻部分共純化出26 個化合物，有 12 個新化合物，其中2 個為新骨架；至少6 個具有顯著活性。大型藻部分共純化出55 個 化合物，有28 個新化合物，其中14 個為新骨架；9 個化合物具有明顯活性。軟珊瑚部分 純化出85 個化合物，有35 個新化合物，兩個為新骨架；11 個具有顯著活性。由此證明本 省的該類海洋生物中所含有的活性或新型化合物十分多樣的，具有進一步開發的潛力。application/pdf38519 bytesapplication/pdfzh-TW國立臺灣大學漁業科學研究所天然物軟珊瑚大型海藻微細藻nature productssoft coralsmicroalgaemacroalgae[SDGs]SDG14journal articlehttp://ntur.lib.ntu.edu.tw/bitstream/246246/20559/1/912323B002008.pdf