Wu Y.-C.JULIA YU-FONG CHANGYI-PING WANGWu Y.-H.HSIN-MING CHENSun A.2021-07-072021-07-0720180929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046681136&doi=10.1016%2fj.jfma.2018.04.012&partnerID=40&md5=322caad0f555568a52bd47d87a7d1bc5https://scholars.lib.ntu.edu.tw/handle/123456789/570222Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) have not yet been reported in recurrent aphthous stomatitis (RAS) patients with concomitant oral lichen planus (OLP/RAS patients). This study mainly assessed the frequencies of serum GPCA, TGA, and TMA (GPCA/TGA/TMA) positivities in 44 OLP/RAS patients. Methods: The frequencies of serum GPCA/TGA/TMA positivities in 44 OLP/RAS patients, OLP/RAS patients of four different subgroups, 520 RAS patients, and 352 healthy control subjects were calculated and compared. Results: We found that 20.5%, 27.3%, and 31.8% of 44 OLP/RAS patients, 75.0%, 100.0%, and 100.0% of 4 OLP/major-typed RAS (OLP/major RAS) patients, 15.0%, 20.0%, and 25.0% of 40 OLP/minor-typed RAS (OLP/minor RAS) patients, 45.5%, 72.7%, and 54.5% of 11 atrophic glossitis-positive OLP/RAS (AG+OLP/RAS) patients, and 12.1%, 12.1%, and 24.2% of 33 AG-negative OLP/RAS (AG?OLP/RAS) patients had the presence of GPCA, TGA, and TMA in their sera, respectively. OLP/RAS patients and OLP/RAS patients of four different subgroups all had significantly higher frequencies of GPCA/TGA/TMA positivities than healthy control subjects. Moreover, OLP/RAS patients had a significantly higher frequency of TMA positivity than RAS patients, and OLP/major RAS and AG+OLP/RAS patients had significantly higher frequencies of GPCA/TGA/TMA positivities than RAS patients. Furthermore, OLP/major RAS patients had significantly higher frequencies of GPCA/TGA/TMA positivities than OLP/minor RAS patients. Conclusion: For OLP/RAS patients, the concomitant OLP may play a role in causing an increased frequency of TMA positivity, and major RAS and the concomitant AG are contributory factors causing the elevated frequencies of GPCA/TGA/TMA positivities. ? 2018[SDGs]SDG3microsome antibody; parietal cell antibody; thyroglobulin antibody; thyroid antibody; thyrotropin; anti-thyroglobulin; autoantibody; thyroid microsomal antibodies; adult; aged; antibody blood level; aphthous stomatitis; Article; clinical article; controlled study; female; glossitis; human; lichen planus; male; mouth ulcer; thyrotropin blood level; adolescent; aphthous stomatitis; blood; case control study; immunology; lichen planus; middle aged; stomach parietal cell; Taiwan; very elderly; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Autoantibodies; Case-Control Studies; Female; Humans; Lichen Planus, Oral; Male; Middle Aged; Parietal Cells, Gastric; Stomatitis, Aphthous; Taiwan; Young Adultjournal article10.1016/j.jfma.2018.04.012297534582-s2.0-85046681136