CHUNG-MIN LIAOMing-Chao L.Chang C.-H.Chen B.-C.Chiang H.-C.2020-01-142020-01-1419991093-4529https://scholars.lib.ntu.edu.tw/handle/123456789/448780Uptake and depuration of dietary and waterborne zinc (Zn(II)) were examined in aquaculture abalone Haliotis diversicolor supertexta and red alga Gracilaria tenuistipitata var. liui using a simple first-order one-compartment bioaccumulation model. A six-compartment physiologically based pharmacokinetic model of the disposition of Zn(II) in abalone key organs was developed to predict tissue distributions. A mean residence time concept was also used to measure the biological persistence for disposition of Zn(II) in each target tissue. The one-compartment kinetic model was successfully fitted to determine uptake and depuration rates based on a 14-d exposure experiment. Results indicated that estimating uptake and depuration rates from depuration and short-term uptake experiments was a reliable method of predicting steady-state bioconcentration and biomagnification factors. Simulations using the six-compartment pharmacokinetic model for both water and food exposure routes indicated that the whole body Zn(II) concentration would reach equilibrium in about 120 d. Zn(II) however did not attain a steady-state in the soft tissue and the shell. It is concluded that a pharmacokinetic model is necessary for assessment of Zn(II) risk to abalone key tissues based on the Zn(II)-dynamics in target compartments.Uptake and depuration of dietary and waterborne zinc (Zn(II)) were examined in aquaculture abalone Haliotis diversicolor supertexta and red alga Gracilaria tenuistipitata var. liui using a simple first-order one- compartment bioaccumulation model. A six-compartment physiologically based pharmacokinetic model of the disposition of Zn(II) in abalone key organs was developed to predict tissue distributions. A mean residence time concept was also used to measure the biological persistence for disposition of Zn(II) in each target tissue. The one-compartment kinetic model was successfully fitted to determine uptake and depuration rates based on a 14-d exposure experiment. Results indicated that estimating uptake and depuration rates from depuration and short-term uptake experiments was a reliable method of predicting steady- state bioconcentration and biomagnification factors. Simulations using the six-compartment pharmacokinetic model for both water and food exposure routes indicated that the whole body Zn(II) concentration would reach equilibrium in about 120 d. Zn(II) however did not attain a steady-state in the soft tissue and the shell. It is concluded that a pharmacokinetic model is necessary for assessment of Zn(II) risk to abalone key tissues based on the Zn(II)-dynamics in target compartments.Abalone; Algae; Bioaccumulation; Pharmacokinetic model; Zinc[SDGs]SDG14Algae; Mathematical models; Pharmacokinetics; Tissue; Zinc; Bioaccumulation; Water pollution; zinc; article; bioaccumulation; chemical reaction kinetics; marine environment; nonhuman; prediction; simulation; steady state; tissue distribution; water pollution; zinc metabolism; algae; Animalia; Eukaryota; Gracilaria tenuistipitata; Gracilaria tenuistipitata; Haliotis corrugata; Haliotis diversicolor; Haliotis diversicolor; Haliotis diversicolor supertexta; Rhodophytajournal article10.1080/109345299093769412-s2.0-0344286672https://www2.scopus.com/inward/record.uri?eid=2-s2.0-0344286672&doi=10.1080%2f10934529909376941&partnerID=40&md5=1c71c3d2cb624c353204499d19d80983