Chen, Jih JungJih JungChenTZONG-HUEI LEECheng, Ming JenMing JenCheng2022-04-142022-04-142022-03-0114203049https://scholars.lib.ntu.edu.tw/handle/123456789/604399Bioassay-guided fractionation of extracts derived from solid cultures of a Herbidospora daliensis originating from Taiwan led to the isolation of five new compounds, for which we propose the name herbidosporadalins A–E (1–5), one isolated for the first time, herbidosporadalin F (6), together with two known compounds (7 & 8). Their structures were elucidated by spectroscopic analyses, including 1D-and 2D-NMR experiments with those of known analogues, and on the basis of HR-EI-MS mass spectrometry, their anti-inflammatory activities were also evaluated. Of these isolates, herbidosporadalin A (1), B (2), F (6) and G (8) showed NO inhibitory activity, with IC50 values of 11.8 ± 0.9, 7.1 ± 2.9, 17.8 ± 1.7, and 13.3 ± 6.5 µM, stronger than the positive control quercetin (IC50 = 36.8 ± 1.3 µM). To the best of our knowledge, this is the first report on 3,4-seco-friedelane metabolites (5, 6 & 8) from the genus Herbidospora.anti-inflammatory activities | Herbidospora daliensis | streptosporangiaceae | triterpenoidsjournal article10.3390/molecules270618872-s2.0-85126967609https://api.elsevier.com/content/abstract/scopus_id/85126967609