Cheng H.-R.JIA-HORNG KAOWu H.-LTAI-CHUNG TSENGCHEN-HUA LIUHUNG-CHIH YANGTUNG-HUNG SUPEI-JER CHENDING-SHINN CHENCHUN-JEN LIU2021-03-092021-03-0920151936-0533https://www.scopus.com/inward/record.uri?eid=2-s2.0-84984550580&doi=10.1007%2fs12072-014-9591-z&partnerID=40&md5=42f1f33391434f409b9038a48b64e547https://scholars.lib.ntu.edu.tw/handle/123456789/551120Background: The clinical significance of serum microRNA-122 (miR-122) has been shown in viral hepatitis B and C, respectively. Specifically, miR-122 stimulates hepatitis C virus (HCV) replication but suppresses hepatitis B virus (HBV) replication. The profile and clinical significance of serum miR-122 in patients with dual chronic hepatitis B and C would be an interesting and important clinical issue.Methods: A total of 76 patients with HBV/HCV dual infection, 105 with HCV monoinfection and 39 with HBV monoinfection were enrolled. All patients received peginterferon alfa-2a (PEG-IFN)-based treatment. Serum miR-122 levels were quantified by using a sensitive hybridization-based assay.Results: At baseline, the serum miR-122 level was lower in HCV-monoinfected patients than in HBV-monoinfected patients, whereas HBV coinfection increased the expression of miR-122. In multivariate analysis, the serum miR-122 level was positively correlated with the serum HBsAg level in patients with HBV/HCV dual infection and those with HBV monoinfection. In dually infected patients who received PEG-IFN-based treatment, a high baseline miR-122 level was positively correlated with a greater reduction of the posttreatment serum HBsAg level.Conclusion: In summary, the serum miR-122 level is highly correlated with the HBsAg level in HBV/HCV dually infected patients and may serve as a biomarker to predict posttreatment HBsAg decline. ? 2014, Asian Pacific Association for the Study of the Liver.[SDGs]SDG3alanine aminotransferase; hepatitis B surface antigen; microRNA 122; peginterferon alpha2a; alpha interferon; antivirus agent; hepatitis B surface antigen; macrogol derivative; microRNA; MIRN122 microRNA, human; peginterferon alpha2a; recombinant protein; adult; Article; controlled study; correlation analysis; female; hepatitis B; Hepatitis B virus; hepatitis C; Hepatitis C virus; human; limit of detection; major clinical study; male; mixed infection; multivariate analysis; prediction; priority journal; prognosis; protein expression; quantitative analysis; RNA analysis; RNA hybridization; treatment outcome; blood; Coinfection; Hepacivirus; Hepatitis B, Chronic; Hepatitis C, Chronic; middle aged; physiology; virus replication; Adult; Antiviral Agents; Coinfection; Female; Hepacivirus; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatitis C, Chronic; Humans; Interferon-alpha; Male; MicroRNAs; Middle Aged; Polyethylene Glycols; Recombinant Proteins; Virus Replicationjournal article10.1007/s12072-014-9591-z257883772-s2.0-84984550580