Hsueh S.-P.Du J.-L.Hsu W.-B.Fang C.-A.Liu H.WON-BO WANG2019-09-022019-09-0220120304-3835https://www.scopus.com/inward/record.uri?eid=2-s2.0-84864044624&doi=10.1016%2fj.canlet.2012.04.019&partnerID=40&md5=87f8efc775e9d8116989e45b9ad61cdehttps://scholars.lib.ntu.edu.tw/handle/123456789/417090HER2-overexpressing cancer cells are resistant to cisplatin (CDDP) and doxorubicin (DXR). Here we report that SV40 T/t-common polypeptide could specifically sensitize HER2-overexpressing cancer cells to CDDP and DXR and specifically enhance CDDP- or DXR-induced apoptosis in these cells. This activity of T/t-common may be attributed to its ability to inhibit Bcl-2 and Bcl-XL and to suppress ERK activity in CDDP- or DXR-treated HER2-overexpressing cancer cells. T/t-common could enhance the antitumor activity of DXR on HER2-overexpressing ovarian tumor in NOD/SCID mice, suggesting that combination therapy using T/t-common and chemotherapeutic agents may provide a new approach for treating HER2-overexpressing cancers. ? 2012 Elsevier Ireland Ltd.en-USAntitumor; Apoptosis; Chemosensitization; HER2; SV40 T/t-common[SDGs]SDG3adenovirus vector; cisplatin; doxorubicin; epidermal growth factor receptor 2; mitogen activated protein kinase; protein bcl 2; protein bcl xl; simian virus 40 T t common polypeptide; unclassified drug; virus protein; animal experiment; animal model; antineoplastic activity; apoptosis; article; cancer cell; cancer cell culture; cancer resistance; chemosensitization; controlled study; drug potentiation; drug sensitivity; enzyme activity; enzyme inhibition; female; flow cytometry; human; human cell; IC 50; mouse; nonhuman; ovary cancer; priority journal; protein expression; protein function; protein synthesis inhibition; tumor xenograft; viral gene delivery system; viral gene therapy; Western blotting; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Apoptosis; bcl-X Protein; Cisplatin; Doxorubicin; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Ovarian Neoplasms; Proto-Oncogene Proteins c-bcl-2; Receptor, erbB-2; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Musjournal article10.1016/j.canlet.2012.04.019225462882-s2.0-84864044624