HORNG-HUEI LIOUWu C.-Y.Chiu Y.-H.Yen A.M.-F.Chen R.-C.TA-FU CHENChen C.-C.Hwang Y.-C.Wen Y.-R.Chen, Tony Hsiu HsiTony Hsiu HsiChen2020-11-032020-11-032009https://www.scopus.com/inward/record.uri?eid=2-s2.0-68349092845&doi=10.1111%2fj.1365-2753.2008.01041.x&partnerID=40&md5=2c145d592d8a43b138f067045514b7d7https://scholars.lib.ntu.edu.tw/handle/123456789/519168Purpose We aimed to quantify the mortality reduction by which the early detection of Parkinson's disease (PD) within a community-based study could reduce the number of advanced cases. Methods Data used in this study were derived from two community-based surveys and from a clinical series of PD cases identified from a medical centre. The cumulative survival by Hoehn-Yahr (H-Y) scale was estimated and the mortality reduction derived from a community-based survey was predicted. Results A total of 117 PD patients were detected through two community-based approaches. By comparing the H-Y stage distribution of screen-detected cases with those from the clinical series, a 22.5% excess in the number of early PD (H-Y stage I and stage II) were identified with screening. The risk ratios of being H-Y stage III or severe for community-based detected cases versus clinical series were 0.49 (95% confidence interval: 0.30-0.78). The total death rate adjusted by H-Y stage distribution was 21% and 28% for cases from community and clinical series, respectively. Conclusions The present study revealed that early detection of PD through a community-based survey may reduce 51% incidence of stage III or more severe PD at diagnosis, leading to a 25% reduction in mortality. ? 2009 Blackwell Publishing Ltd.[SDGs]SDG3adult; aged; article; controlled study; female; health survey; human; major clinical study; male; mortality; Parkinson disease; prevalence; priority journal; risk factor; screening test; survival rate; Academic Medical Centers; Adult; Aged; Early Diagnosis; Female; Health Care Surveys; Humans; Male; Mass Screening; Middle Aged; Mortality; Parkinson Disease; Proportional Hazards Models; Severity of Illness Index; Survival Analysis; Taiwanjournal article10.1111/j.1365-2753.2008.01041.x196742132-s2.0-68349092845