CHIA-HSUIN CHANGMING-SHIANG WUYU-TING CHANGMING-CHU CHANGCHIA-TUNG SHUNLiu C.-Y.Lin J.-T.2020-10-152020-10-1520020929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036983873&partnerID=40&md5=edca137a834577fbcf874d58908ed779https://scholars.lib.ntu.edu.tw/handle/123456789/517201Background and Purpose: People living on Matzu, a group of small islets, have the highest mortality rate from gastric cancer (GC) in Taiwan. Intestinal metaplasia (IM) is a precursor lesion of GC. We therefore conducted a gastroscopic screening program in this district to evaluate the risk factors associated with IM. Methods: A total of 274 residents of Matzu, aged 30 years or older, underwent testing for anti-Helicobacter pylori IgG antibody and serum pepsinogen (PG) I/PG II levels, and gastroscopic examination. Univariate and multivariate logistic regression models were used to identify risk factors associated with IM in terms of odds ratios (ORs) and 95% confidence intervals (CIs). Results: Among the 274 subjects, 118 (43%) were confirmed to have IM by histologic examination. Individuals aged 60 years or older had a 2.66 times higher risk (95% CI 1.38-5.13) of having IM, as compared with those less than 60 years of age. Subjects with duodenal ulcer had a 60% lower risk of coexisting IM (OR, 0.40; 95% CI, 0.19-0.83). Meanwhile, subjects with gastric ulcer were not at increased risk of IM (OR, 0.84; 95% CI, 0.34-2.08). Low serum PG I level, low PG I/PG II ratio, and positive anti-H. pylori IgG antibody, were associated with IM in the univariate analysis. While age and duodenal ulcer maintained their independent effects in the multivariate analysis, only a low PG I/PG II ratio and H. pylori positivity were significantly associated with IM. Conclusions: This study of residents of Matzu found that age and H. pylori infection are risk factors for IM, while subjects with duodenal ulcer have a lower incidence of coexisting IM. Low PG I/PG II ratio is a potential noninvasive biomarker of IM.[SDGs]SDG3bacterium antibody; biological marker; immunoglobulin G; pepsinogen I; pepsinogen II; adult; age; aged; antibody detection; article; cancer mortality; clinical examination; comorbidity; controlled study; disease association; duodenoscopy; duodenum cancer; esophagoscopy; female; gastroscopy; Helicobacter pylori; histopathology; human; incidence; intestine metaplasia; major clinical study; male; mass screening; multivariate logistic regression analysis; precancer; prevalence; risk assessment; risk factor; stomach cancer; stomach ulcer; Taiwan; Adult; Aged; Antibodies, Bacterial; Cross-Sectional Studies; Female; Helicobacter pylori; Humans; Immunoglobulin G; Intestines; Male; Metaplasia; Middle Aged; Pepsinogen A; Precancerous Conditions; Risk Factors; Stomach Neoplasms; Taiwanjournal article126328162-s2.0-0036983873