內科Alberts, M. J.M. J.AlbertsBhatt, D. L.D. L.BhattMas, J.-L.J.-L.MasOhman, E. M.E. M.OhmanHirsch, A. T.A. T.HirschRother, J.J.RotherSalette, G.G.SaletteGoto, S.S.GotoSmith, S. C.S. C.SmithLiau, C.-S.C.-S.LiauWilson, P. W.F.P. W.F.WilsonSteg, Ph. G.Ph. G.Steg2010-06-212018-07-112010-06-212018-07-112009http://ntur.lib.ntu.edu.tw//handle/246246/185810To determine 3-year event rates in outpatients with vascular disease enrolled in the REduction of Atherothrombosis for Continued Health (REACH) Registry. Methods and results REACH enrolled 67 888 outpatients with atherothrombosis [ established coronary artery disease (CAD), cerebrovascutar disease, or peripheral arterial disease (PAD)], or with at least three atherothrombotic risk factors, from 44 countries . Among the 55 499 patients at baseline with symptomatic disease, 39 675 were eligible for 3-year follow-up, and 32 247 had data available (81% retention rate). Among the symptomatic patients at 3 years, 92% were taking an antithrombotic agent, 91% an anti hypertensive, and 76% were on Upid- lowering therapy. For myocardial infarction (Ml)/ stroke/vascutar death, 1 - and 3-year event rates for all patients were 4.2 and 11.0%, respectively. Event rates (MI/ stroke/vascutar death) were significantly higher for patients with symptomatic disease vs. those with risk factors only at 1 year (4.7 vs. 2.3%, P < 0.001) and at 3 years (12.0 vs. 6.0%, P < 0.001). One and 3-year rates of MI /stroke/vascular cleath/ rehospitatization were 14.4 and 28.4 %, respectively, for patients with symptomatic disease. Rehospitalization for a vascular event other than Mi/ stroke/ vascular death was common at 3 years (19.0% overall; 33.6% for PAD ; 23.0% for CAD). For patients with symptomatic vascular disease in one vascular bed vs. multiple vascular beds, 3-year event rates for MI/stroke/ vascular death/ rehospitalization were 25.5 vs. 40.5% (P < 0.001). Conclusion Despite contemporary therapy, outpatients with symptomatic atherothrombotic vascular disease experience high rates of recurrent vascular events and rehospitalizations.en-USAtherothrombosisRisk factorsCoronary artery diseaseCerebrovascular diseasePeripheral arterial disease[SDGs]SDG3acetylsalicylic acid; anticoagulant agent; antidiabetic agent; antihypertensive agent; antilipemic agent; antithrombocytic agent; hydroxymethylglutaryl coenzyme A reductase inhibitor; aged; artery disease; article; cardiovascular risk; cerebrovascular disease; coronary artery disease; female; follow up; heart infarction; hospital readmission; human; major clinical study; male; priority journal; recurrent disease; stroke; vascular disease; Aged; Ambulatory Care; Anticoagulants; Antihypertensive Agents; Coronary Artery Disease; Diabetes Complications; Female; Follow-Up Studies; Hospitalization; Humans; Hypertension; Hypoglycemic Agents; Male; Myocardial Infarction; Obesity; Peripheral Vascular Diseases; Recurrence; Registries; Risk Factors; Smoking; Strokejournal article10.1093/eurheartj/ehp355