SUNG-HSIN KUOYang, Shi-YiShi-YiYangHUANG-CHUN LIENCHIAO LOCHING-HUNG LINYEN-SHEN LUANN-LII CHENGKING-JEN CHANGCHIUN-SHENG HUANG2020-03-052020-03-0520132314-6133https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890011993&doi=10.1155%2f2013%2f562197&partnerID=40&md5=540eb195232ed3a513bdd1e9eee52eb1https://scholars.lib.ntu.edu.tw/handle/123456789/470178Given the critical role of CYP19 in estrogen synthesis, we investigated the influence of CYP19 gene polymorphisms on the clinical outcome of lymph node- (LN-) negative, hormone receptor- (HR-) positive early breast cancers. Genotyping for the CYP19 polymorphisms rs4646 (A/C), rs1065779 (A/C), CYP19 (TTTA)n (short allele/long (S/L) allele using the 7 TTTA repeat polymorphism as the cut-off), and rs1870050 (A/C) was performed on 296 patients with LN-negative, HR-positive breast cancers. All patients received adjuvant hormonal therapy. Associations were examined between these 4 genotypes and 6 common haplotypes of CYP19 and distant disease-free survival (DDFS), disease-free survival (DFS), and overall survival (OS). Patients were divided into the 6 subhaplotypes of CCLA (41.1%), AASA (17.1%), CASA (11.9%), CCLC (8.9%), CCSA (7.5%), AASC (8.9%), and others (4.6%). In premenopausal patients, haplotype AASA was significantly associated with a poor DDFS (adjusted hazard ratio (aHR), 3.3; P = 0.001), DFS (aHR, 2.5; P = 0.0008), and OS (aHR, 2.9; P = 0.0004) after adjusting for age, tumor size, tumor grade, estrogen receptor status, progesterone receptor status, chemotherapy, pathology, adjuvant hormone therapy, menopausal status, and radiotherapy. Furthermore, haplotype AASA remained a negative prognostic factor for premenopausal patients receiving adjuvant chemotherapy in terms of DDFS (aHR, 4.5; P = 0.0005), DFS (HR, 3.2; P = 0.003), and OS (HR, 6.4; P = 0.0009). However, in postmenopausal patients, haplotype AASA was not associated with a poor prognosis, whereas the AASC haplotype was significantly associated with a poor DFS (aHR, 3.1; P = 0.03) and OS (aHR, 4.4; P = 0.01). Our results indicate that, in patients with LN-negative, HR-positive breast cancers, genetic polymorphism haplotype AASA is associated with poor survival of premenopausal women but does not affect survival of postmenopausal women. ? 2013 Sung-Hsin Kuo et al.en[SDGs]SDG1[SDGs]SDG3aromatase; estrogen receptor; progesterone receptor; aromatase; estrogen; estrogen receptor; adult; aged; article; breast cancer; cancer hormone therapy; cancer prognosis; cancer size; cancer survival; cohort analysis; disease free survival; DNA isolation; electrophoresis; female; genetic polymorphism; genotype; haplotype; hormone receptor positive breast cancer; human; human cell; human tissue; major clinical study; overall survival; polymerase chain reaction; postmenopause; premenopause; single nucleotide polymorphism; biosynthesis; breast tumor; genetics; haplotype; lymph node; middle aged; neoplasm; pathology; premenopause; prognosis; very elderly; Adult; Aged; Aged, 80 and over; Aromatase; Breast Neoplasms; Disease-Free Survival; Estrogens; Female; Haplotypes; Humans; Lymph Nodes; Middle Aged; Neoplasms, Hormone-Dependent; Polymorphism, Single Nucleotide; Premenopause; Prognosis; Receptors, Estrogenjournal article10.1155/2013/562197243249642-s2.0-84890011993