PEI-JEN LOUYI-HO YOUNG2020-10-272020-10-2719981019-6102https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031979878&partnerID=40&md5=46c8cfcf5f8e2f371a5d9e5833cf720dhttps://scholars.lib.ntu.edu.tw/handle/123456789/518341Background: The incidence of hypercholesterolemia has gradually increased owing to the changes in diet habits. In our previous studies we have reported the ultrahigh frequency hearing loss caused by hypercholesterolemia. The main concern of the present study is to evaluate the effect of hypercholesterolemia on equilibrium function of vertigo patients. Methods: We retrospectively review the laboratory data and equilibrium function test results of 3360 fresh cases with inner ear symptoms who visited the National Taiwan University Hospital from September, 1991 to August, 1994. Data of hyperlipidemic patients were compared with age, sex- matched control groups and were statistically analysed. Results: Three hundred and seven patients of this series sustain hypercholesterolemia, of whom 142 have hyperlipidemic vestibular disorders, 83 have central vertigo, 54 suffer from peripheral vertigo, and the rest 28 are others. Abnormal optokinetic after nystagmus (OKAN) is the most frequent finding(74%) in patients with hyperlipidemic vestibular disorders. Statistical differences in OKAN also exist between hypercholesterolemic and cholesterol-normal groups in the entities of verte-brobasilar artery insufficiency and Meniere's disease. Conclusion: Abnormal OKAN is the main abnormal ENG finding of hypercholesterolemic vertigo patients.Hypercholesterolemia; Optokinetic after nystagmus[SDGs]SDG3article; female; human; hypercholesterolemia; major clinical study; male; optokinetic nystagmus; prevalence; proprioception; vertebrobasilar insufficiency; vertigojournal article2-s2.0-0031979878