JIA-FENG WUChen C.-H.Hsieh R.-P.Shih H.-H.Chen Y.-H.Li C.-R.Chiang C.-Y.Shau W.-Y.YEN-HSUAN NIHUEY-LING CHENHONG-YUAN HSUMEI-HWEI CHANG2021-01-042021-01-0420060022-3476https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646833969&doi=10.1016%2fj.jpeds.2005.12.025&partnerID=40&md5=a5723b679bcea650ad18b2b7f526e851https://scholars.lib.ntu.edu.tw/handle/123456789/537082Objective: To conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (HLA) polymorphisms and the seroconversion of hepatitis B e antigen (HBeAg). Study design: In the prospective cohort study, 81 HBeAg-positive children with chronic hepatitis B virus (HBV) infection from 40 unrelated families were recruited and followed-up regularly for a mean period of 17.70 ± 3.23 years. The association between HLA antigen and the age at HBeAg seroconversion was analyzed using Cox regression model with shared frailties under left truncation and right censorship. Results: HLA-B61 and HLA-DQB1*0503 antigens predicted a higher HBeAg seroconversion rate (relative incidence = 6.17 and 3.22, P = .024 and .017, respectively). Within-family frailty in our sibling cohort study demonstrated a negligible or a low degree of within-family correlation with spontaneous HBeAg seroconversion in each HLA antigen. Conclusions: HLA class I antigen B61 and class II antigen DQB1*0503 are associated with earlier HBeAg seroconversion in Taiwanese children with chronic HBV infection. ? 2006 Elsevier Inc. All rights reserved.[SDGs]SDG3biological marker; hepatitis B antigen; HLA DQB1 antigen; adolescent; adult; article; child; chronic hepatitis; controlled study; DNA polymorphism; female; follow up; hepatitis B; HLA typing; human; infant; long term care; major clinical study; male; priority journal; seroconversion; sibling; Taiwanjournal article10.1016/j.jpeds.2005.12.025167378792-s2.0-33646833969