Chang Y.-Y.Chen A.Wu X.-M.Hsu T.-P.Daisy L.-Y.Chen Y.-H.YEN-WEN WUHUNG-JU LINRON-BIN HSUCHII-MING LEESHOEI-SHEN WANGLo M.-T.MING-FONG CHENYEN-HUNG LIN2020-03-052020-03-0520141449-1907https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906248632&doi=10.7150%2fijms.8083&partnerID=40&md5=3a38f5318d322ac28b4b79869616fa84https://scholars.lib.ntu.edu.tw/handle/123456789/470928Background: Galectin-3 (Gal-3) shows the ability of survival prediction in heart failure (HF) patients. However, Gal-3 is strongly associated with serum markers of cardiac extracellular matrix (ECM) turnover. The aim of this study is to compare the impact of Gal-3 and serum markers of cardiac ECM turnover on prognostic prediction of chronic systolic HF patients. Methods: Serum Gal-3, brain natriuretic peptide (BNP), extracellular matrix including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2, 9 (MMP-2, 9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Cox regression analysis was used for survival analysis. Results: A total of 105 (81 male) patients were enrolled. During 980±346 days follow-up, 17 patients died and 36 episodes of HF admission happened. Mortality of these patients was significantly associated with the log PIIINP (β= 15.380; P=0.042), log TIMP-1(β= 44.530; P=0.003), log MMP-2 (β= 554.336; P<0.001), log BNP (β= 28.273; P=0.034). Log Gal-3 (β= 7.484; P=0.066) is borderline associated with mortality. Mortality or first HF admission of these patients was significantly associated with the log TIMP-1(β= 16.496; P=0.006), log MMP-2 (β= 221.864; P<0.001), log BNP (β= 5.999; P=0.034). Log Gal-3 (β= 4.486; P=0.095) only showed borderline significance. In several models adjusting clinical parameters, log MMP-2 was significantly associated with clinical outcome. In contrast, log Gal-3 was not. Conclusion: The prognostic strength of MMP-2 to clinical outcome prediction in HF patients is stronger than Gal-3. ? Ivyspring International Publisher.[SDGs]SDG3brain natriuretic peptide; collagen; galectin 3; gelatinase A; gelatinase B; procollagen type 1 aminopropeptide; procollagen type 3 aminopropeptide; tissue inhibitor of metalloproteinase 1; unclassified drug; brain natriuretic peptide; galectin 3; gelatinase A; gelatinase B; peptide fragment; procollagen; procollagen Type I N-terminal peptide; procollagen Type III-N-terminal peptide; tissue inhibitor of metalloproteinase 1; adult; article; comparative study; controlled study; correlational study; disease association; extracellular matrix; female; human; major clinical study; male; mortality; predictive value; prognosis; protein blood level; receiver operating characteristic; sensitivity and specificity; survival rate; systolic heart failure; aged; blood; middle aged; pathology; systolic heart failure; Aged; Female; Galectin 3; Heart Failure, Systolic; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Predictive Value of Tests; Procollagen; Tissue Inhibitor of Metalloproteinase-1journal article10.7150/ijms.8083251702922-s2.0-84906248632