Chiou H.-YHuang Y.-LDeng M.-CChang C.-YJeng C.-RTsai P.-SYang CPang V.FChang H.-W.Chang, H.-W.H.-W.ChangChang H.-W.VICTOR FEI PANGHUI-WEN CHANGPEI-SHIUE TSAICHIAN-REN JENGCHIA-YI CHANG2021-07-262021-07-26201718651674https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928139109&doi=10.1111%2ftbed.12357&partnerID=40&md5=554c365484c98bb4e96e488c7ec9febahttps://scholars.lib.ntu.edu.tw/handle/123456789/573177New variants of porcine epidemic diarrhoea virus (PEDV), which emerged in Taiwan in late 2013, have caused a high morbidity and mortality in neonatal piglets. To investigate the molecular characteristics of the spike (S) gene of the emerging Taiwan PEDV strains for a better understanding of the genetic diversity and relationship among the Taiwan new variants and the global PEDVs, full-length S genes of PEDVs from nine 1–7?day-old piglets from three pig farms in the central and southern Taiwan were sequenced and analysed. The result of phylogenetic analysis of the S gene showed that all the Taiwan PEDV strains were closely related to the non-S INDEL strains from US, Canada and China, suggesting a common ancestor for these strains. As compared with the historic PEDVs and CV777-based vaccine strains, the nine Taiwan PEDV variants shared almost the same genetic signatures as the global non-S INDEL strains, including a series of insertions, deletions and mutations in the amino terminal as well as identical mutations in the neutralizing epitopes of the S gene. The high similarity of the S protein among the Taiwan and the globally emerged non-S INDEL PEDV strains suggests that the Taiwan new variants may share similar pathogenesis and immunogenicity as the global outbreak variants. The development of a novel vaccine based on the Taiwan or the global non-S INDEL strains may be contributive to the control of the current global porcine epidemic diarrhoea outbreaks. ? 2015 Blackwell Verlag GmbHcoronavirus spike glycoprotein; amino acid sequence; animal; chemistry; Coronavirus Infections; genetics; metabolism; phylogeny; physiology; pig; Porcine epidemic diarrhea virus; sequence alignment; Swine Diseases; Taiwan; veterinary; virology; Amino Acid Sequence; Animals; Coronavirus Infections; Phylogeny; Porcine epidemic diarrhea virus; Sequence Alignment; Spike Glycoprotein, Coronavirus; Swine; Swine Diseases; Taiwan[SDGs]SDG3coronavirus spike glycoprotein; amino acid sequence; animal; chemistry; Coronavirus Infections; genetics; metabolism; phylogeny; physiology; pig; Porcine epidemic diarrhea virus; sequence alignment; Swine Diseases; Taiwan; veterinary; virology; Amino Acid Sequence; Animals; Coronavirus Infections; Phylogeny; Porcine epidemic diarrhea virus; Sequence Alignment; Spike Glycoprotein, Coronavirus; Swine; Swine Diseases; Taiwanjournal article10.1111/tbed.12357259039982-s2.0-84928139109