2012-06-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/693644摘要：生物例如細菌、病毒和細胞，透過胺基酸、醣類、和核酸等基本建構單元之直接自組裝，而擁有完整的微/奈米結構及生物化學功能。藉由微調分子間與分子內作用力之方式，目前已經發展及建立出許多以超分子化學為基礎之不同策略及方法，將天然或人工合成分子進行自組裝，而生成具備天然材料中之重要結構與功能的有機及奈米結構材料。上述由具生物活性基本單元組裝而成之超分子奈米結構，在生物材料之應用方面，如病毒模仿體、治療藥劑的載體和組織工程的支架等，亦極具潛力。於本產學合作計畫中，我們嘗試研究醣-縮氨酸共聚高分子合成及其超分子之組裝及其可能之應用。由於一些與生化現象相關的生物分子片段之參與，將可增加此些醣-縮氨酸共聚高分子系統之結構與功能上之多樣性及複雜性。我們相信，藉由對這些高分子之適當設計，其形成之超分子奈米結構可以更有效率地傳遞用於治療功用之藥物。於本計畫中，我們將會探索利用這些超分子奈米結構作為肝癌治療藥劑載體應用之可能性。<br> Abstract: Living organisms such as bacteria, viruses, and cells possess well-defined micro/nanostructures and biological functions through the directed self-assembly of building blocks, namely, amino acids, saccharides, and nucleic acids. By fine-tuning of intra- and intermolecular interactions, various strategies based on supramolecular chemistry have been developed for the self-assembly of natural or synthetic molecules into soft and nanostructured materials with some essential features of natural materials. Supramolecular nanostructures assembled from these bioactive functional building blocks hold a great significance not only for their basic research, but also for their potential for use in different biomaterial applications such as virus mimics, carriers for therapeutic agents, scaffoldsfor tissue engineering, and so on. In this research porject, we propose to study the synthesis andsupramolecular assembly of saccharide-peptide copolymers and their potential applications. The diversity and complexity of structures and functions in these polymer systems can be increased due to the involvement of these biological segments in a number of biochemical phenomena. We believe, through ingenious design of these polymers, the supramolecular nanostructures can be useful for efficient delivery of therapeutic agents. The possibility of employing these supramolecular nanostructures as carriers for therapeutic agents against liver cancer will be explored in this proposed research.標靶性醣-聚氨酸高分子載體於肝癌治療之研究