Chen, Szu-YingSzu-YingChenCHANG-FU WUWu, CharleneCharleneWuCHANG-CHUAN CHANHwang, Jing-ShiangJing-ShiangHwangTA-CHEN SU2022-03-242022-03-242022-02-090013936Xhttps://scholars.lib.ntu.edu.tw/handle/123456789/601992The relationships between the elemental constituents of PM2.5 and atherosclerosis remain limited, especially in young populations. This study included 755 subjects aged 12-30 years in the Taipei metropolis. A land use regression model was used to estimate residential annual mean concentrations of PM2.5 and eight elemental constituents. We evaluated the percent differences in carotid intima-media thickness (CIMT) with PM2.5 and elemental constituent exposures by linear regressions. Interquartile range increments for PM2.5 (4.5 μg/m3), sulfur (108.6 ng/m3), manganese (2.0 ng/m3), iron (34.5 ng/m3), copper (3.6 ng/m3), and zinc (20.7 ng/m3) were found to associate with 0.92% (95% confidence interval (CI): 0.17-1.66), 0.51% (0.02-1.00), 0.36% (0.05-0.67), 0.98% (0.15-1.82), 0.74% (0.01-1.48), and 1.20% (0.33-2.08) higher CIMTs, respectively. Factor analysis identified four air pollution source-related factors, and the factors interpreted as traffic and industry sources were associated with higher CIMTs. Stratified analyses showed the estimates were more evident in subjects who were ≥18 years old, females, or who had lower household income. Our study results provide new insight into the impacts of source-specific air pollution, and future research on source-specific air pollution effects in young populations, especially in vulnerable subpopulations, is warranted.enatherosclerosis; carotid intima-media thickness; elemental constituents; particulate matter; young population[SDGs]SDG11[SDGs]SDG15journal article10.1021/acs.est.1c06347351388452-s2.0-85124900111https://scholars.lib.ntu.edu.tw/handle/123456789/597448