CHE-FENG CHANGGoods, Brittany ABrittany AGoodsAskenase, Michael HMichael HAskenaseBeatty, Hannah EHannah EBeattyOsherov, ArtemArtemOsherovDeLong, Jonathan HJonathan HDeLongHammond, Matthew DMatthew DHammondMassey, JordanJordanMasseyLandreneau, MargaretMargaretLandreneauLove, J ChristopherJ ChristopherLoveSansing, Lauren HLauren HSansing2022-02-152022-02-1520210039-2499https://scholars.lib.ntu.edu.tw/handle/123456789/594571Brain tissue-resident microglia and monocyte-derived macrophages (MDMs) are innate immune cells that contribute to the inflammatory response, phagocytosis of debris, and tissue repair after injury. We have previously reported that both microglia and MDMs transition from proinflammatory to reparative phenotypes over days after an intracerebral hemorrhage (ICH). However, their individual functional properties in the brain remain largely unknown. Here we characterized the differences between microglia and MDMs and further elucidate their distinct activation states and functional contributions to the pathophysiology and recovery after ICH.encerebral hemorrhage; immunity, innate; macrophages; microglia; phagocytosis[SDGs]SDG3journal article10.1161/STROKEAHA.120.032196338402252-s2.0-85104984043WOS:000644656300042https://scholars.lib.ntu.edu.tw/handle/123456789/562311