臺大醫院-內科部;臺大醫院新竹分院;臺大醫院-檢驗醫學部;臺大醫學院-醫學檢驗暨生物技術學系暨研究所;Sun, Hsin-YunHsin-YunSunChang, Sui-YuanSui-YuanChangSheng, Wang-HueiWang-HueiShengChen, Mao-YuanMao-YuanChenHsieh, Szu-MinSzu-MinHsiehTseng, Yu-TzuYu-TzuTsengLu, Ching-LanChing-LanLuYang, Chia-JuiChia-JuiYangWu, HsiuHsiuWuLiu, Wen-ChunWen-ChunLiuWu, Cheng-HsinCheng-HsinWuHung, Chien-ChingChien-ChingHungChang, Shan-ChwenShan-ChwenChang吳政翰2014-02-142018-07-112014-02-142018-07-112012http://ntur.lib.ntu.edu.tw//handle/246246/258754Objective: To assess the incidence of acute pancreatitis in human immunodeficiency virus-positive patients with triglyceride (TG) greater than 500 mg/dL after highly active antiretroviral therapy. Methods: Sequential TG levels during follow-up and episodes of acute pancreatitis were retrospectively reviewed in 347, 417, and 571 patients enrolled in periods 1 (2000-2002), 2 (2003-2005), and 3 (2006-2008), respectively. The incidence of acute pancreatitis, defined as consistent clinical symptoms and elevated amylase and/or lipase levels, was estimated. Results: A total of 5356 TG measurements were performed during the follow-up for 698.22, 884.14, and 1215.69 person-years in periods 1, 2, and 3, respectively. Overall, 9.89% of patients had at least one TG greater than 500 mg/dL. Five patients with TG less than 500 mg/dL developed acute pancreatitis. The crude incidences of acute pancreatitis were 0.6%, 0.5%, and 0.2%, and the incidence rates were 2.86, 2.26, and 0.82/1000 person-years in periods 1, 2 and 3, respectively (all, P > 0.05). The incidence rates of acute pancreatitis when TG levels were less than 500, less than 1000, and less than 1500 mg/dL ranged from 1.2 to 4.9/1000 person-years, whereas it was 0/1000 person-years when TG levels were greater than 500, greater than 1000, and greater than 1500 mg/dL, respectively. Conclusion: The risk of acute pancreatitis was low among human immunodeficiency virus-positive patients who developed hypertriglyceridemia after receiving highly active antiretroviral therapy.110 bytestext/htmlhuman immunodeficiency virushighly active antiretroviral therapyhypertriglyceridemiaacute pancreatitisincidence rate[SDGs]SDG3http://ntur.lib.ntu.edu.tw/bitstream/246246/258754/1/index.html