Lin W.-Y.WEI-SHIUNG YANGLee L.-T.Chen C.-Y.Liu C.-S.Lin C.-C.KUO-CHIN HUANG2021-01-142021-01-1420060307-0565https://www.scopus.com/inward/record.uri?eid=2-s2.0-33744489576&doi=10.1038%2fsj.ijo.0803240&partnerID=40&md5=bf5fb2749cc22807503c554b6b09b75ahttps://scholars.lib.ntu.edu.tw/handle/123456789/540745Objective: To investigate the relationship between the metabolic syndrome and its related factors among non-diabetic pre- and post-menopausal women in North Taiwan. Design: A cross-sectional study in a medical center in North Taiwan. Subjects: Five hundred and ninety-four, non-diabetic middle-aged women (age range=40-64 years, mean=48.9±5.4 years) were recruited. Measurements: The fasting plasma glucose, insulin, lipids levels and anthropometric indices were measured. The homeostasis model assessment was applied to estimate the degree of insulin resistance (HOMA-IR). Metabolic syndrome was defined by using the National Cholesterol Education Panel (NCEP) criteria and modified NCEP criteria (waist circumference >80 cm). Results: The prevalence of metabolic syndrome was 6.2% using NCEP criteria, and 8.9% using modified NCEP criteria. Post-menopausal women had a higher prevalence of metabolic syndrome and its individual components compared to pre-menopausal women except hyperglycemia and low HDL-C. In multiple logistic regression analysis with adjustment for age and menopausal status, both BMI and HOMA-IR were independently associated with the metabolic syndrome. Conclusion: The prevalence of metabolic syndrome was higher in post-menopausal than pre-menopausal women. Both obesity and insulin resistance may play an important role in the development of metabolic syndrome among the middle-aged women in North Taiwan. ? 2006 Nature Publishing Group All rights reserved.[SDGs]SDG3glucose; high density lipoprotein cholesterol; insulin; lipid; adult; anthropometry; article; controlled study; diabetes mellitus; female; glucose blood level; homeostasis; human; hyperglycemia; insulin blood level; insulin resistance; lipid blood level; major clinical study; menopause; metabolic syndrome X; multivariate logistic regression analysis; obesity; postmenopause; prevalence; priority journal; Taiwan; waist circumference; Adult; Anthropometry; Asian Continental Ancestry Group; Blood Glucose; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Diabetes Complications; Female; Humans; Insulin; Insulin Resistance; Lipids; Metabolic Syndrome X; Middle Aged; Obesity; Postmenopause; Premenopause; Prevalence; Taiwanjournal article10.1038/sj.ijo.0803240164325382-s2.0-33744489576