黃慧璧臺灣大學：獸醫學研究所許名宜Hsu, Ming-YiMing-YiHsu2007-11-282018-07-092007-11-282018-07-092005http://ntur.lib.ntu.edu.tw//handle/246246/59932家塵及塵蟎是犬異位性皮膚炎重要的過敏原。本研究的目的是要探討家塵及塵蟎在台北地區異位性皮膚炎犬隻的感受性。本實驗依病史、臨床症狀、理學檢查及皮膚學檢查收集患犬，並進一步進行皮內試驗試驗及判讀。最後依照臨床症狀及皮內試驗結果收集一百隻患犬進行研究。其中包含五十隻公犬及五十隻母犬，年齡分佈自一歲到十四歲，平均為5.7歲，共計二十三種犬種包含於內。皮內試驗結果對家塵及塵蟎陽性反應率分別為15% (15/100) 及3% (3/100)，對家塵及塵蟎均產生陽性反應比率為68% (68/100)。本研究未發現種別或年齡因子與兩種過敏原陽性反應之間的關係。性別及體重在統計上有顯著影響。以年齡、性別、體重、品種與發病年齡與家塵陽性、塵蟎陽性、對任一陽性做關連比較，發現體重與陽性反應有相關。對兩種過敏原產生陽性反應比率比對單一過敏原產生陽性比率高出許多。兩種過敏原之間的陽性有強烈相關。未來的研究可繼續探討過敏原之間的交互關係。本研究顯示皮內試驗對家塵、塵蟎過敏原的高陽性率，證實家塵、塵蟎為台北地區犬異位性炎的常見且重要過敏原。Host dust and dust mite are important allergens in canine atopic dermatitis. The purpose of this study was to investigate sensitivity to house dust and dust mite in atopic dogs in Taipei city. One hundred atopic dogs were enrolled according to history, clinical signs ,physical and dermatological exams. Intradermal test with house dust and dust mite were performed and investigated. The diagnosis of atopic dermatitis of each dog was based upon the clinical manifestations compatible to criteria, and results of intradermal skin tests. fifty females and fifty males aged from one to forteen years old with twenrt-three breeds . The mean age of this series was 5.7years. Among these One hundred dogs, eighty six dogs (86%) exhibited positive reactions to either house dust or dust mite, or both. Positive reactions to house dust and dust mite were 15% (15/100) and 3% (3/100) respectively. Positive reaction to both allergens was 68% (68/100). No breed, age predilection found in this series. Sex and body weight were statistical related to positive reaction (either house or dust mite), Analyses between sex, age, body weight and positive reaction to house dust, positive reaction to dust mite, and positive reaction either to house dust or dust mite reveals statistically related between body weight and positive reaction. Percentage of cases exhibited positive reaction to both allergens was significantly higher than that of cases reacted to either allergen alone. This suggested that positive reaction to either allergen would be associated to each other. Further investigation would be needed to clarify the cross-reaction between house dust and dust mites. This study suggests the high positive rate of intradermal tests to house dust and dust mite. House dust and dust mite are common and important allergens in atopic dogs at Taipei area.目錄 頁次 目錄 ------------------------------------------------------------------------------------------- iv 中文摘要 ------------------------------------------------------------------------------------- vi 英文摘要 ------------------------------------------------------------------------------------- vii 圖次 ------------------------------------------------------------------------------------------- viii 表次 ------------------------------------------------------------------------------------------- ix 第一章 緒言 --------------------------------------------------------------------------------- 1 第二章 文獻探討 ---------------------------------------------------------------------------- 3 第一節 異位性皮膚炎-總論 --------------------------------------------------------- 4 一、發生率與盛行率 ------------------------------------------------------------- 4 二、遺傳因子 ---------------------------------------------------------------------- 6 三、異位性皮膚炎的病理生理學 ---------------------------------------------- 8 四、異位性皮膚炎與免疫球蛋白 ---------------------------------------------- 8 五、異位性皮膚炎與炎症反應 ------------------------------------------------- 10 六、犬與人異位性皮膚炎之比較 ---------------------------------------------- 12 第二節 犬異位性皮膚炎之臨床症狀與診斷 --------------------------------------- 13 一、 異位性皮膚炎的臨床症狀 ----------------------------------------------- 13 二、 異位性皮膚炎的特徵-目前的共識 ------------------------------------- 16 三、 異位性皮膚炎的臨床診斷 ----------------------------------------------- 20 第三節 過敏原 ------------------------------------------------------------------------- 22 一、 過敏原的分類 -------------------------------------------------------------- 22 二、過敏原的進入途徑 -------------------------------------------------------- 22 三、環境過敏原-家塵及塵蟎 ------------------------------------------------- 24 四、過敏原之選擇 -------------------------------------------------------------- 27 五、過敏原的標準化 ----------------------------------------------------------- 28 六、過敏原的稀釋及保存 ----------------------------------------------------- 29 第四節 過敏原測試 ----------------------------------------------------------------- 31 一、活體測試 -------------------------------------------------------------------- 32 二、皮內試驗各論 -------------------------------------------------------------- 33 第三章 材料與方法 ------------------------------------------------------------------------ 43 第一節 材料 ----------------------------------------------------------------------- 44 第二節 方法與步驟 -------------------------------------------------------------- 47 第三節 統計方法 ----------------------------------------------------------------- 48 第四章 結果 --------------------------------------------------------------------------------- 51 第一節 測驗對象之基本資料 -------------------------------------------------- 52 第二節 測驗對象之皮內測試結果 -------------------------------------------- 54 第三節 統計結果 ----------------------------------------------------------------- 57 第五章 討論 --------------------------------------------------------------------------------- 82 第一節 異位性皮膚炎患犬之基本資料 -------------------------------------- 83 第二節 異位性皮膚炎患犬之診斷 -------------------------------------------- 87 第三節 皮內試驗結果 ----------------------------------------------------------- 88958441 bytesapplication/pdfen-US犬異位性皮膚炎家塵塵蟎canine atopic dermatitishouse dustdust mitethesishttp://ntur.lib.ntu.edu.tw/bitstream/246246/59932/1/ntu-94-R90629024-1.pdf