Hong, W.-S.W.-S.HongChen, Y.-P.Y.-P.ChenDai, T.-Y.T.-Y.DaiHuang, I.-N.I.-N.HuangMING-JU CHEN2018-09-102018-09-102011http://www.scopus.com/inward/record.url?eid=2-s2.0-80051722680&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/362207In this study, we assessed the anti-asthmatic effects of heat-inactivated Lactobacillus kefiranofaciens M1 (HI-M1) and its fermented milk using different feeding procedures and at various dosage levels. The possible mechanisms whereby HI-M1 has anti-allergic asthmatic effects were also evaluated. Ovalbumin (OVA)-allergic asthma mice that have been orally administrated the HI-M1 samples showed strong inhibition of production of T helper cell (Th) 2 cytokines, pro-inflammatory cytokines, and Th17 cytokines in splenocytes and bronchoalveolar fluid compared to control mice. An increase in regulatory T cell population in splenocytes in the allergic asthma mice after oral administration of H1-M1 was also observed. In addition, all of the features of the asthmatic phenotype, including specific IgE production, airway inflammation, and development of airway hyperresponsiveness, were depressed in a dose-dependent manner by treatment. These findings support the possibility that oral feeding of H1-M1 may be an effective way of alleviating asthmatic symptoms in humans. ? 2011 American Chemical Society.Allergy; asthma; kefir; Lactobacillus kefiranofaciens; Th17[SDGs]SDG3Airway inflammation; Allergic asthma; asthma; Cytokines; Dosage levels; Dose-dependent manner; kefir; Lactobacillus kefiranofaciens; Oral administration; Ovalbumins; Splenocytes; T cells; Th17; Cell culture; Cell proliferation; Diseases; Fermented milk; Mammals; allergen; animal; asthma; Bagg albino mouse; dairy product; female; heat; immunology; Lactobacillus; microbiology; mouse; review; Allergens; Animals; Asthma; Cultured Milk Products; Female; Hot Temperature; Lactobacillus; Mice; Mice, Inbred BALB C; Lactobacillus kefiranofaciens; Musjournal article10.1021/jf201913x