外科HUANG, CHIUN-SHENGCHIUN-SHENGHUANG2009-01-082018-07-112009-01-082018-07-111999http://ntur.lib.ntu.edu.tw//handle/246246/96180The incidence of breast cancer has increased greatly in Taiwan over the past 2 decades. Increased exposure to environmental carcinogens, including aryl aromatic amines, as a result of the economic boom, is suspected to be one factor contributing to this increase. The enzyme N- acetyltransferase 2 (NAT2) determines the rate of metabolism of aryl aromatic amines, and therefore the NAT2 slow acetylator genotype is associated with an increased risk of cancer. Our present case-control study of 150 breast cancer patients and 150 healthy controls in Taiwan was performed to explore the association between NAT2 genetic polymorphism and individual susceptibility to breast cancer. A structured questionnaire was used to collect relevant information regarding all known or suspected risk factors of breast cancer. The NAT2 genotype was determined using the polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP) assay in 139 cases and 133 controls, and 28.8% and 21.1%, respectively, were found to have slen-USCIGARETTE-SMOKINGACETYLATION POLYMORPHISMCOLORECTAL-CANCERALLELIC LOSSRISKPHENOTYPE[SDGs]SDG3journal article